Efficacy of volume-targeted ventilation for the treatment of neonatal respiratory distress syndrome / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To investigate the efficacy of volume-targeted ventilation (VTV) for the treatment of neonatal respiratory distress syndrome (NRDS).</p><p><b>METHODS</b>Fifty-two neonates with NRDS between August 2013 and August 2015 were randomly divided into two groups: VTV and pressure-controlled ventilation (PCV) (n=26 each ). A/C+Vc+ ventilation model was applied in the VTV group, and A/C+PCV ventilation model was applied in the PCV group. Arterial blood gas analysis was performed at 6, 24, and 48 hours after ventilation. The following parameters were observed: time of invasive ventilation, duration of oxygen therapy, mortality, and the incidence rates of hypocapnia, pneumothorax, ventilator-associated pneumonia (VAP), grade III-IV periventricular-intraventricular hemorrhage (PVH-IVH), periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP).</p><p><b>RESULTS</b>Compared with the PCV group, the VTV group had a significantly shorter time of invasive ventilation (P<0.05) and significantly lower incidence rates of hypocapnia, VAP, and PVL (P<0.05); however, there were no significant differences in the duration of oxygen therapy, mortality, and incidence rates of pneumothorax, grade III-IV PVH-IVH, BPD, and ROP.</p><p><b>CONCLUSIONS</b>VTV has a better efficacy than PCV in the treatment of NRDS, and is worthy of clinical promotion and application.</p>

Three kinds of mechanical ventilations for treating neonatal respiratory distress syndrome / 中华实用儿科临床杂志

Objective To contrast the curative effects of proportional assist ventilation (PAV) and high frequency oscillatory ventilation(HFOV) and synchronized intermittent mandatory ventilation(SIMV) on treatment of neonatal respiratory distress syndrome(NRDS).Methods A retrospective study was carried out based on clinical data of 161 neonates.The research subjects were the neonates who had been hospitalized from May 2008 to May 2012 in Jiangmen Central Hospital and received one of the mechanical ventilation methods.The subjects were divided into 3 groups according to used mechanical ventilation mode they received,and their curative effect was compared.Results Fortythree cases in PAV group were treated by PAV,58 cases in HFOV group received HFOV,and 60 cases in SIMV group received SIMV.In comparison with sex ratio,gestational age of birth,birth weight,dose of poractant alfa injection there was no differece among 3 groups(all P ＞0.05).The number of effective cases in PAV group,HFOV group and SIMV group was 37 cases,57 cases,52 cases,respectively;the invalid cases including 6 cases,1 case,8 cases in 3 groups,respectively.Among the 3 groups,the curative effect was significantly different(x2 =6.197,P =0.045),curative effect of PAV group was not different from that of SIMV group(x2 =0.008,P =0.928),curative effect of HFOV group was better than that of PAV group and SIMV group(x2 =3.986,P =0.046 ;x2 =4.114,P =0.043).Conclusion The curative effect of HFOV for neonatal respiratory distress syndrome was better,which could be recommended.