A Case fo Drug Eruption following the Use of Gold Preparation / 대한피부과학회지

Gold preparation had been used frequently in the past in the treatment of rheumatoid arthritis, tuberculosis and lupus erythematosua, etc. It is still used. when other more potent remedies, such as steroid, failed. We report a case of drug eruption following the use of gold preparation. A 38 year-old female was referred to our department from orthopedic surgery because of generalized, multiple, pin head sized, violaceous and flat topped papules of 1 x 2 mm in size and mucosal erosions and ulcers following gold therapy for rheumatoid arthritis. She had received 5 intramuscular injections of gold preparation (Myochrysine'), 220mg in total amounts. Our clinical impression was lichen planus like drug eruption, but histopathological picture disclosed nonapecific dermatitis. The eruption had disappeared gradually following oral administration of antihistaminics and prednisolone and daily starch tub baths.

Two Different Penicillin Preparations in the Treatment of Gonorrhhea / 대한피부과학회지

Penicillin is still the first choice of drug in the treatment of gonorrhea. The ever lowering sensitivity of Neisseria gonorrhoeae to penicillin and the emergence of PPNG (Penicillinase Producing Neisseria Gonorrhoeae) in the Far East and other parts of the world neceessitate reapprisal of treatrnent schedules with penicillin for gonococcal infections. In Korea, no authentical study in this regard has been done recently. The presence of intracellular gram r.egative diplococci in urethral smear as weIl as the presence of oxidase positive typical, round, convex, smooth, glistening, tratmslucent, greyish colonies of 0.5 to 2mm in diameter a 24 hours composed of grarn negative diplococci are used for presump'ive evidence of gonococccal infection 224 male patients with acnte uncomplicated gonococal infections were treated one of following regimens. Regimen A: 4.8mega unit combicillin (3.6mega unit procaine penicillin+l.2 mega unit sodium penicillin) i.m.. preceded by 1gm probenecid p.o., Regirnen B: 4.8 mega unit procaine penicillin i.m. preceded by 1gm probenecid P.O. Regimen A showed 14 failures(11.3% arnong 124. Regimen B showed 19 failures (19%) among 100 It is suggested that in Korea sesnsitivity to penicillin of Yeisseria gonorrhoeae is quite low.

A Case of Idipathic Calcinosis of the Scrotum / 대한피부과학회지

The idiopathic calcinosis of the scrotum (Shapiro, 1970) is usually multiple, asymtomatic nodules of the scrotal skin which begins m childhood or early adult life, increase in the size and numbers, and sometimes breakdown to discharge chalky contents. Clinically they are most often misdiagnosed as cysts. The forty eight years old male patient visited our hospital on Oct. 14, 1980, because of multiple asymtomatic scrotal masses which are pin head to walnut sized. There is no family history of calcification, scrotal or otherwise. Histology shows naked amorphous masses in the dermis without any evidence of residual cysts, and is acicular clefts in the masses. Most of the tumors were surgically removed in 5 sessions.

A Case fo Pigmented Lichen Sclerosus et Atrophicus / 대한피부과학회지

Lichen sclerosus et atrophicus (LSA) is an uncommon condition of the skin with small white macular or atrophic plaques which predominantly affects the genital regions of middle aged and elderly women. We present an atypical case of LSA on a 58 year old woman. The patient had a brownish-black colored patch of 2.5 * 7.0 cm in size on the right clavicular area of one year's duration. The histopatholgy of the lesion disclosed classical findings of LSA. A marked incontinence of pigment is noted in the upper dermis which accounts for the clinical picture of the lesion. She was treated with topical hydrocortisone cream resulting in a marked diminution of pigmentation.

Nitroblue Tetrazolium dye Reduction Test (NBT) in Patients with Pulmonary and Skin Tuberculosis / 대한피부과학회지

No abstract available.

One Case of Erythromelalgia / 대한피부과학회지

Erythromelalgia is a rare disease characterized by burning pain of the extremities associated with erythema and increased temperature of the skin. A case of erythromelalgia was reported with review of literatures. It seemed that this is the first reported case in Korean literatures. patient was 12 years old male having erythematous swelling associated with burning pain on his feet and lower legs for five years. Immersion of his feet in warm water quickly, increased the pain but cold water gave prompt relief that he soaked his feet for many hours during the day and night. No specific abnormalities were noticed in Iaboratory studies, Treatment with various topical, systemic medication revealed of unfavorable result.

A Case of Early Congenital Syphilis / 대한피부과학회지

We report one case of 1 month old male with early congenital syphilis Who represented the characteristic clinical features and laboratory findings including darkfield examindtion and quantitative VDRL test. The histopathologic findings of the patients skin biopsy specimen showed extravasation of erythrocytes and perivascular infiltration of plasma cells were found. in addition to the previous described findings by Fraser. He was managed by daily injection of 200,000 units of aqueous procaine penicillin for 8 days and then three injections of 150,000 units of PA.M at two days intervals with excellent effect

A Case of Generalized Pustular Psoriasis in Infancy / 대한피부과학회지

A case of familiar benign chronic pemphigus is reported. A 41 years old housewife has recurrent history of developing grouped vesicular eruptions with erythematous erosion on the intertrigenous area since 29 years of her age. The lesions were used to aggrevated in summer and improved in autumn. Familiar history revealed same disease of her grand mother, father, 44 year old elder sister and 39 year old younger sister. All of whom had similar clinical signs and symptoms. Routine physical and Iaboratoryfindings were within normal limits. The histopathological findings, from vesicular eruption of the lateral aspect of neck, showed multilocular suprabasal clefts with acantholsis, villi formation and hyperkeratosis. The lesions were improved hy the local application of corticostcroidoid ointrnent only.

Clinical Trials of Tavegyl in Dermatologic Field / 대한피부과학회지

Clinical trials were done to obtain ifnormation on the clinical efficacy, tolerance and side effects of a new antihistarnine, Mecloprodine(Tavegyl), in various skin disordetrs. A total of 48 patients suffered from various skin disorders as urticaria, eczema etc. v ere treated with 2mg. daily for 3 days to 15 days according to state of disorders. The results are as follows. 1. Improvement was noticed in 79.2% of total patients(38/48). 2. Tavegyl was efiective in all 8 cases of acute urticaria and most cases(7/8) of urticaria factitia. 3. Among 19 cases of chronic urticaria, improvement was noticed in 13 cases(68. 49). Improvement was alsa noticed in all 6 cases of eczema. 5. Drowsiness and weakness cccurred in 6.2% of cases(3/48).