RESUMEN
Background: Chronic Rhinosinusitis (CRS) places a relativelylarge socioeconomic burden on developed nations, yet remainsa difficult disease to treat. Vitamin D3 (VD3) deficiency isreported to be associated with increased incidence of allergicairway diseases. The ability of VD3 to augment innate andadaptive immune responses has sparked interest in itsimmunologic role in allergy. The objective of the present studyis to evaluate the relationship between serum vitamin D leveland Chronic Rhinosinusitis (CRS).Materials & Methods: A total of 25 patients with ChronicRhinosinusitis were enrolled and were labelled as study group.Also, 25 healthy subjects without history of sinusitis and noendoscopic evidence of inflammatory sinus disease wereenrolled as control group. Complete demographic details of allthe patients were obtained. Blood samples were obtained fromall the patients and were sent to laboratory for assessment ofVitamin D levels. In the laboratory, ELISA technique was usedfor assessment of serum Vitamin D levels. All the results wererecorded in Microsoft excel sheet and were analysed by SPSSsoftware.Results: Mean Vitamin D levels of the study group patientswas found to be 31.8 nmol/L and that of control group werefound to be 43.2 nmol/L respectively. Vitamin D levels weresignificantly lower in study group as compared to control group.Conclusion: Vitamin D levels are significantly altered inChronic Rhinosinusitis patients. However; their role inpathogenesis of the disease need further exploration.