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Journal of Zhejiang University. Science. B ; (12): 806-816, 2006.
Artículo en Inglés | WPRIM | ID: wpr-251851

RESUMEN

MicroRNAs (miRNAs) constitute a novel, extensive class of small RNAs (approximately 21 nucleotides), and play important gene-regulation roles during growth and development in various organisms. Here we conducted a homology search to identify homologs of previously validated miRNAs from silkworm genome. We identified 24 potential miRNA genes, and gave each of them a name according to the common criteria. Interestingly, we found that a great number of newly identified miRNAs were conserved in silkworm and Drosophila, and family alignment revealed that miRNA families might possess single nucleotide polymorphisms. miRNA gene clusters and possible functions of complement miRNA pairs are discussed.


Asunto(s)
Animales , Secuencia de Bases , Bombyx , Análisis por Conglomerados , Biología Computacional , Métodos , Drosophila melanogaster , Prueba de Complementación Genética , Genoma , MicroARNs , Metabolismo , Datos de Secuencia Molecular , Familia de Multigenes , Polimorfismo de Nucleótido Simple , Homología de Secuencia de Ácido Nucleico , Programas Informáticos , Termodinámica
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