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Objective To determine the content icariin in the extract of Gushuling. Methods HPLC method was performed on Luna C18 column (250 mm?4.6 mm, 5 ?m). The mobile phase consisted of acetonitrile- water (30∶70) and the UV detective wavelength was set at 270 nm. Results The curve of icariin was linear within 0.416～2.496 ?g, Y=2.0?106X-53 810 (r =0.999 9). Conclusion HPLC method is simple, rapid and accurate, and it is suitable for ananlysis of icariin content in extract of Gushuling .
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OBJECTIVE:To analyze the general features of adverse drug reactions(ADRs)caused by hepatitis B vaccine.METHODS:72national case reports of ADRs induced by hepatitis B vaccine in recent10years were classified and analyzed statistically.RESULTS:The affected patients ranged in age from1year to 40 years,with more males than females;Most ADRs occurred with in 30 minutes after the medication;The ADRs were characterized by allergies in clinic,even allergic shock.CONCLUSIONS:It is important to manage the ADRs caused by hepatitis B vaccine for the safety of medication.
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OBJECTIVE： To prepare etoposide－ bovine serum albumin－ microspheres (VP－ BSA－ MS)and to study the distribution and pharmacokinetics of VP－ BSA－ MS in mice. METHODS: The drug concentrations in various tissues were determined by high－ performance liquid chromatograph (HPLC). RESULTS: The VP－ BSA－ MS was injected into mice and (47.88± 2.56 )％ of the total dosage was detected in lung tissue 15min after administration， the pharmacokinetical equation was C=149.0 897e－ 1.7 780t＋ 3.9 627e－ 0.0 398t — 153.0 524e－ 3.5 054t. CONCLUSION： The VP－ BSA－ MS showed remakable targeting action to the lung and the pharmacokinetic regularity could be discribed as two－ compartment model
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OBJECTIVE:To review the occurrence of ophthalmic injuries and analyse the relationship between the injuries and the kinds of drugs used and the route of administration METHODS:The cases of drug-induced ophthalmic injuries which were reported in medical journals published from 1960 to 2000 year were collected and analysed RESULTS:There were 967 cases of drug-induced ophthalmic injuries caused by 154 kinds of drug The clinical manifestations of ophthalmic injuries included ocular pigmentation,visual disturbance,loss of sight and injuries to cornea,conjunctiva,optic nerve,retina or optic papilla,and the inducing drugs were mostly antimicrobials,central nervous system and circulatory system drugs,such as chlorpromazine,perphenazine,amiodaron,ethambutol etc CONCLUSION:Drug-induced ophthalmic injuries caused by systemic administering drugs in commonly-used dosage and route pertain to ADRs The ophthalmic injuries caused by local application of drugs to the eyes result from improper drugs used,faulty manipulation and unsuitable applications of drugs during or after operations
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OBJECTIVE:To evaluate the bioavailability of two nimesulide preparations.METHODS:A total of 20 healthy male volunteers were enrolled in a randomized crossover study in which the subjects were randomly assigned to receive single dose of 200 mg nimesulide orally disintegrating tablets(test)or nimesulide tablets(reference).The plasma concentrations of nimesulide were determined by RP-HPLC,and the pharmacokinetic parameters and bioavailability were calculated with DAS program.RESULTS:The main pharmacokinetic parameters of nimesulide test and reference preparations were as follow:AUC0～24:(54.67?18.25)vs.(56.15?15.54)?g?h?mL-1;AUC0～∞:(56.38?18.03)vs.(57.63?15.26)?g?h?mL-1;Cmax:(7.61?2.72)vs.(7.50?2.19)?g?mL-1;tmax:(3.83?1.39)and(3.80?1.28)h.The relative bioavailability of nimesulide or-ally disintegrating tablets as against nimesulide tablet was(98.7?22.9)%.CONCLUSION:Nimesulide test and reference preparations were bioequivalent.
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OBJECTIVE:To study the compatible stability of puerarin injection with 10 commonly-used drugs.METHODS:The changes in appearance,pH,particulate and puerarin content after mixing with 10 drugs were observed and assayed.RESU_LTS & CONCLUSION:Puerarin injection mixing with adenosine triphosphate,coenzyme A and ribavirin showed significant change in pH,which indicats that they are incompatable each other,however,when puerarin injection was mixed with vitamin B6,potassium chloride,etamsylate,cimetidine,gentamycin,amikacin and erythromycin,no significant changes in pH,particulate and puerarin content were found,which indicates their compatibility.
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OBJECTIVE:To prepare etoposide-bovine serum albumin-microspheres (VP-BSA-MS)and to study the distribution and pharmacokinetics of VP-BSA-MS in mice. METHODS: The drug concentrations in various tissues were determined by high-performance liquid chromatograph (HPLC). RESULTS: The VP-BSA-MS was injected into mice and (47.88?2.56 )% of the total dosage was detected in lung tissue 15min after administration,the pharmacokinetical equation was C=149.0 897e-1.7 780t+3.9 627e-0.0 398t —153.0 524e-3.5 054t. CONCLUSION:The VP-BSA-MS showed remakable targeting action to the lung and the pharmacokinetic regularity could be discribed as two-compartment model