RESUMEN
<p><b>OBJECTIVE</b>To compare the effect of laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) on liver function and immune function.</p><p><b>METHODS</b>Forty-two patients with normal liver function underwent LC (n=21) or OC (n=21) according to the patients' preference. One day before and 7 days after the operations, the liver functions (ALT, AST, TBIL, ALB) and immune functions (CD3, CD4, CD8, NK cell percentage, IgA, IgM, IgG and C3, C4) of the patients were measured.</p><p><b>RESULTS</b>No statistical differences were found in the liver functions or immune functions between the two groups after the operation.</p><p><b>CONCLUSION</b>LC and OC show no significant difference in the effects on the liver function and immune function.</p>