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Objective:To explore the differences of attention bias performance between patients with heroin dependence in methadone maintenance treatment(MMT) and healthy controls.Methods:A total of 38 heroin dependent patients in the Fourth People's Hospital of Huainan from January 2018 to September 2018 were selected as MMTgroup, and 32 gender-and age-matched healthy controls were selected as healthy control(HC) group.The attention bias was evaluated by Emotional Stroop Task, and the difference between the two groups was compared.Results:The error number of the herion-related words in Emotional Stroop Task of MMT group was lower than that of HC group[0.75(2, 5) vs.1(0, 2)], the difference was statistically significant( Z=-2.184, P=0.029). The number of errors in point and neutral words and reaction time of point, neutral word and clue word had no statistically significant differences between MMT group and HC group[1(0, 4) vs.1(0, 2); 3(2, 5) vs.2(2, 3); (1 055.14±303.50)ms vs.(985.40±173.71)ms, (1 126.89±347.82)ms vs.(1 022.76± 173.62)ms; (1 188.53±371.80)ms vs.(1 113.23±225.11)ms]( Z=-1.331, P=0.183; Z=-1.723, P=0.085; t=1.150, P=0.254; t=1.539, P=0.129; t=1.001, P=0.320). There were no statistically significant differences in attention bias influenced by the dosage and duration of methadone between MMT group and HC group(all P>0.05). Conclusion:These results demonstrate that heroin dependence patients in MMT have attentional bias in heroin-related words.Methadone has no effect on attention bias in patients with heroin dependence during maintenance treatment intervention.
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Objective To observe and analyze the effect of different external fixation methods on catheter related urinary tract infection (CAUTI).Methods The clinical data of 86 patients suffered from indwelling catheters were retrospectively analyzed .According to the different external fixation of indwelling catheter , the patients were divided into observation group (n=43) and control group (n=43).The control group received drainage tube fixed in the bedside the legs go below ,the observation group received drainage tube fixed on the bed after upper thigh walking . The incidence of complications was analyzed in the two groups .Results The incidence rates of CAUTI ,leakage of urine,skin indentation of the observation group were 13.95％,6.98％ and 2.33％,respectively,which were lower than those of the control group (34.88％,30.23％ and 23.26％),there were statistically significant differences between the two groups (χ2 =11.869,17.848,19.630,all P<0.05).The incidence rates of 2,3 degree pain and pain in the observation group were 0.00％,4.65％,6.98％,respectively,which in the control group were 2.33％, 6.98％,9.30％,respectively,the differences were not statistically significant (χ2 =2.357,0.495,0.359,all P>0.05).Conclusion For the patients of indwelling catheter ,drainage tube is fixed on the bed by the upper thigh walking is helpful to reduce skin pressure , reduce catheter infection and urine leakage rate , and can improve the comfort degree of patients ,it is worthy of clinical popularization and application .
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Objective To evaluate the treatment of acute cerebral infarction of 4 kinds of drug cost-effective-ness.Methods A retrospective analysis was performed on 207 patients with acute cerebral infarction,according to the drug formulation of patients treatment,they were divided into four groups: group A (alprostadil),group B(Oza-grel),group C(Dan red injection),group D(Xuesaitong),the curative effects and adverse reactions were observed and analyzed by using pharmacoeconomic cost-effectiveness method.Results The costs of groups A,B,C and D were 5 248.6,4 253.7,4 475.8,3 501.2 yuan,respectively;The effective rates were 92.2%,83.7%,87.5%,76.9%, respectively;The cost effectiveness ratio(C/E) were 56.93,50.82,51.15,45.53,respectively;A,B,C group compared with the incremental cost-D group,the effect of ratio(△C/△E) were 107.2,110.7,91.9;The incidence of adverse reactions were 3.9%,6.1%,12.5%,11.5%.Conclusion Alprostadil group scheme was the best treatment scheme.