RESUMEN
Sox9 is a member of the Sox family of E groups,and it plays a role in gender determination and differentiation,tumor development and organ development.In the process of pancreatic development,Sox9 and its crosstalk with the Notch,Wingless and INT-1 (Wnt) and fibroblast growth factor (Fgf) pathways are involved in the proliferation and differentiation of early pancreatic endocrine progenitor cells.It is a versatile factor of Sox9 in the regulation network of pancreatic endocrine development.Endocrine beta cells are the only cells that secrete insulin.The absolute or relative inadequate of insulin will lead to increase blood glucose levels and then lead to the occurrence of diabetes.The study of pancreatic endocrine development provides a new idea to explore the pathogenesis of diabetes.In this paper,the effects of Sox9 and its transcriptional regulation mechanisms on pancreatic endocrine development are summarized.