RESUMEN
Blood gas analysis was performed in 65 normal adults, 90 patients with chronic bronchitis and 173 with cor pulmonale. Altogether 401 determinations were done. It was found that the P(A-a)O2 was significantly higher in patients with chronic bronchitis and cor pulmonale than in normal adults. When considered comprehensively with the parameters of pulmonary ventilation and diffusion functions and the ventilation/perfusion ratio, P(A-a)O2 possesses definite clinical significance. In various kinds of acid-base disturbance, P(A-a)O2 is the highest in decompensatory respiratory acidosis, and the lowest in compensatory respiratory acidosis.
RESUMEN
Twenty-five mongrel dogs were randomized into 3 groups;the animals of group Ⅰ were traumatized with bone marrow extract,those of group Ⅱ were similarily traumatized and then treated with anisodamine,and those of group Ⅲ received saline only and served as control.The specimens of arterial and venous blood were collected and bronchoalveolar lavage fluid (BALF) and lung homogenate were obtained after the animal was killed.The activity of superoxide dismutase (SOD) and the concentration of lipid peroxides (LPO) were determined.Meanwhile,the clinical manifestations,blood gas analysis.chest radiography,and pathological examinations were performed or observed.It was found there were following findings:(1)In group I,SOD activity and LPO level in the lung homogenate and BALF were markedly elevated immediately after injury,which suggests that there had been a rapid production of active oxygen.As a result.various degrees of lung damages were pricipitated.(2)In group Ⅱ,an increase of SOD activity and LPO level in the blood,lung homogenate and BALF:The elevation was more marked than that in group Ⅲ but less marked than that in group Ⅰ.which indicates that there was a relatively of less amount of active oxygen production by the interference anisodamine.(3)In group Ⅱ,no significant changes of SOD activity and LPO livel were found.Our findings suggest that active oxygen is likely to play a very important role in the pathogenesis of acute lung damages in respiratory distress syndrome.
RESUMEN
The levels of CEA, Lys, Fr and ?2-MG of serum and brochoalveolar lavage fluid (BALF) were determined in 99 patients with inflammatory lung diseases and 23 healthy subjects for controls. Their levels in BALF were compared between diseased and normal sides of lungs. The value of diagnosis of individual formulas was suggested. The combined ditermination of multiple biomarkers in serum and BALF can help to raise the positivity and spcificity of diagnosis of lung cancer.