Effect of Yishen Zhuangyang Cream on penile hemodynamics in ED patients / 中华男科学杂志

Objective@#To observe the effect of Yishen Zhuangyang Cream (YZC) on the hemodynamic parameters of the penile cavernous artery in ED patients and explore its pharmacological mechanisms.@*METHODS@#Ninety-two outpatients with ED were randomly assigned to receive YZC (n = 60) or placebo ( the control group, n = 32), all for 4 weeks. Comparisons were made between the two groups of patients in the IIEF-5 scores, penile erectile hardness (PEH) scores and the hemodynamic parameters of the penile cavernous artery before and after treatment.@*RESULTS@#The IIEF-5 and PEH scores were both significantly increased in the YZC group after treatment in comparison with the baseline (19.18 ± 3.56 vs 12.63 ± 3.78, P 0.05). The rate of therapeutic effectiveness was remarkably higher in the YZC than in the control group (73.33% vs 21.88%, Z = －4.665, P < 0.01).@*CONCLUSIONS@#YZC can improve the erectile function of ED patients by increasing IIEF-5 and PEH scores but has no significant effect on penile hemodynamics. The pharmacological mechanisms of YZC acting on ED need to be further studied.

Low-dose daily de-escalatory administration of tadalafil for psychological erectile dysfunction / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the effect of low-dose daily de-escalatory administration of tadalafil on psychological erectile dysfunction (ED).</p><p><b>METHODS</b>We randomized 84 psychological ED patients into an observation and a control group of equal number to receive low-dose daily de-escalatory administration and on-demand medication of tadalafil, respectively, both for 2 months. We compared the scores on IIEF-5 and erection hardness (EHS) between the two groups before and after the treatment.</p><p><b>RESULTS</b>The treatment and follow-up were accomplished for 79 cases, with 5 withdrawals in the control group. The IIEF-5 and EHS scores were remarkably improved in both the observation and control groups after treatment. The rate of therapeutic effectiveness was significantly higher in the observation group than in the control (95.2% vs 86.5%, P < 0.05).</p><p><b>CONCLUSION</b>Low-dose daily de-escalatory administration of tadalafil is highly effective and even better than on-demand medication of tadalafil for psychological ED.</p>

Low-dose testosterone undecanoate capsules combined with tadalafil for late-onset hypogonadism accompanied with ED / 中华男科学杂志

<p><b>OBJECTIVE</b>To observe the clinical effect of low-dose testosterone undecanoate capsules combined with tadalafil on late-onset hypogonadism (LOH) accompanied with ED.</p><p><b>METHODS</b>Ninety cases of LOH accompanied with ED who met the inclusion criteria were randomly divided into a control group and a combination therapy group, the former treated with tadalafil and the latter with low-dose testosterone undecanoate capsules combined with tadalafil. The LOH symptoms, IIEF-5 scores, sexual encounter profile (SEP) scores, prostate volumes, and the levels of total testosterone (TT), free testosterone (FT) and prostatic specific antigen (PSA) were recorded and compared between the two groups before and after treatment.</p><p><b>RESULTS</b>The IIEF-5 and SEP scores and the TT and FT levels were 20.6 +/- 3.8, 4.02 +/- 1.08, (15.4 +/- 3.4) nmol/L and (0.391 +/- 0.062) nmol/L, respectively, in the combination therapy group after treatment, significantly higher both than 15.7 +/- 3.9, 1.49 +/- 0.82, (10.1 +/- 1.2) nmol/L and (0.200 +/- 0.045) nmol/L before treatment (P < 0.01) and than 8.6 +/- 3.6, 3.50 +/- 1.21, (10.2 +/- 1.2) nmol/L and (0.210 +/- 0.051) nmol/L in the control group after treatment (P < 0.01).</p><p><b>CONCLUSION</b>Low-dose testosterone undecanoate capsules combined with tadalafil has a definite clinical effect and no obvious adverse reactions in the treatment of LOH accompanied with ED.</p>