The role of HIRA gene in the pathogenesis of congenital heart disease / 国际儿科学杂志

Conotruncal defects(CTD) is a kind of severe cardiovascular abnormality, which is the major cause of death in rinatal pelriod. Some researches suggest that CTD and 22q11 microdeletion had close relationship. In addition, HIRA gene is located in 22q11, which was speculated as a candidate gene in CTD.