Two Cases of Metronidazole-Induced Neurotoxicity Lacking of Clinico-Radiological Correlation

Metronidazole is an antimicrobial agent widely used for the treatment of trichomoniasis, giardiasis, amebiasis, and anaerobic bacterial infections. It has been reported that metronidazole-induced neurotoxicity is associated with responsible lesions on brain MRI. We report 2 patients with metronidazole-induced neurotoxicity, who had no responsible lesions on brain MRI for their neurological deficits. The pathogenic mechanisms are discussed.

Three Cases of Demyelinating Disease mimicking Primary Brain Tumor

Inflammatory demyelinating diseases are usually diagnosed based on characteristic clinical and radiological findings. However, some demyelinating diseases have been presented as growing large mass-like lesions, and it is difficult to differentiate those demyelinating lesions from brain tumors. We report three cases of demyelinating diseases mimicking brain tumors. These cases suggest that the inflammatory demyelinating diseases have a wide spectrum and they can present with the same radiological features of brain tumors.