Asponchimides A-E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis / 中国天然药物

Five new racemic N-acetyldopamine (NADA) trimers, asponchimides A-E (1-5), were isolated from Aspongopus chinensis, a prominent traditional Chinese medicinal insect employed for alleviating pain, treating indigestion, and addressing kidney ailments. Compounds 1-5 were successfully resolved by chiral high-performance liquid chromatography (HPLC), yielding five pairs of enantiomers: (+)- and (-)-asponchimides A-E (1a/1b-5a/5b). Their structural identities were discerned by extensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR), and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Compounds 1-5 are pioneering instances of NADA trimers featuring a Δ7 double bond. When subjected to a series of bioassays, a majority of the compounds exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-induced RAW 264.7 cells.

From Zhu Danxi's Medical Records for the Clinical Diagnosis and Treatment Characteristics / 浙江中医药大学学报

Objective] From the analysis of Zhu Danxi's life with its clinical diagnosis treatment characteristics, in order to learn, inherit Zhu's academic thought essence and clinical characteristics of diagnosis and treatment. [Method] Danxi Xinfa, Gezhi Yu, golden hook on Xuan, pulse, because treatment contained case as the foundation, combined with his classic discussion and academic thoughts, this case's treatment after diagnosis and treatment, and a comprehensive analysis of its characteristics and the implication behind the academic thought. [Results] The clinical diagnosis and treatment analysis of Zhu has simple effect, using ginseng rhizome; diagnosis and treatment, good physique differentiation of Qi and blood deficiency, the similarities and differences;using four Jun Siwu;the main and col ateral channels disease, fine trial of yin and Yang and the characteristics. Zhu Danxi was good at Yin on treatment, and miscel aneous duties in the Qi, blood, phlegm, stagnation and other academic thoughts. [Conclusion] Zhu Danxi with concise and comprehensive, distinctive features, if deeply analyzing cases with Zhu life classic discussion and academic features, we can have a more profound understanding of the clinical diagnosis and treatment rules and characteristics, to pass its characteristics, enhance the ability of clinical diagnosis and treatment of disease.