RESUMEN
Objective To investigate the effect of exercise diary on arm exercise compliance ofpatients with peripherally inserted centralcatheter (PICC). Methods Thirty patients with PICC hospitalized in our hospital from June to August in 2017 were selected as the control group, where the patients received guidance on functional exercises through arm exercise videos and routine methods. Another thirty-two patients hospitalized in our hospital from September to November of 2017 were selected as the observation group, where in addition to the same treatment as in the control group and these patients received interventions using their self-designed exercise diary for a total of 31 days. Their compliance with functional exercises before and after intervention and the incidences of venous thrombosis after intervention were compared between the two groups. Results After interventions, the compliance rate of arm exercises in the observation group was significantly higher than that of the control group (90.6% vs. 26.7%, P＜0.05). The incidence of venous thrombosis in the observation group was significantly lower than that of the control group (3.1% vs. 30.0% , P＜0.05). Conclusions Exercise diary can improve the arm exercise compliance of PICC patients and prevent the occurrence of venous thrombosis. It is worthy of clinical application and promotion.
RESUMEN
Present research aims to investigate the repairing effect of polylactic acid-trimethylene carbonate/GNDF slowrelease catheter on the injured femoral nerve fiber. Adult SD male rats as the subjects were divided into two groups, the GDNF group and the control group, and received the surgery to remove the nerve from the exposed left femoral nerves. Thereafter, rats in the GNDF group and the control group received the GNDF or normal saline, and we evaluated the changes in rats, including the morphological, functional and electrophysiological changes of regenerated nerves. Regenerated axons were found in each group, but enormous regeneration of axons was only identified in GDNF group. Further analysis showed that: At the 4th, 8th and 12th weeks, areas of the regenerated nerves in GDNF group were [0.95 +/- 0.06] mm2, [1.14 +/- 0.07] mm2 and [1.22 +/- 0.06] mm2, respectively; in the control group, these were [0.15 +/- 0.01] mm2, [0.25 +/- 0.07] mm2 and [0.52 +/- 0.05] mm2, respectively. These showed that the outcome of GDNF group was superior to that of control group. In GDNF group, quantities of the myelinated fiber were [0.8119×104 +/- 0.0637×104], [1.3371×104 +/- 0.0460×104] and [1.7669×104 +/- 0.0542×104]; while in control group, these were [0.2179×104 +/- 0.0097×104], [0.3490×104 +/- 0.0329×104] and [0.7737×l04 +/- 0.0788×104]. Again, these results also indicated that the outcome of GDNF group was superior to that of the control group [p<0.05]. In GDNF group, the average diameters of myelinated fibers were [2.25 +/- 0.17] micro m, [2.42 +/- 0.14] micro m and [2.80 +/- 0.10] micro m, which were significantly better than [1.24 +/- 0.08] micro m, [1.43 +/- 0.14] micro m and [1.82 +/- 0.14] micro m in the control group. Degrees of fiber myelination in the GDNF group were [0.71 +/- 0.03], [0.64 +/- 0.03] and [0.6l +/- 0.0l], respectively, which were also significantly higher than [0.02 +/- 0.01], [0.04 +/- 0.01] and [0.06 +/- 0.02] in the control group [p<0.01]. At the 12th week after surgery, HE staining was performed to observe the histological changes in quadriceps femoris for evaluation of atrophy in each group. In the GDNF group, significant amelioration was found in the atrophy of quadriceps femoris with an average area of myofiber of [84.95 +/- 3.92] %, while the area of the control group was [57.95 +/- 5.78] %, suggesting that the outcome of the GDNF group was better than that of the control group [p<0.05]. Electrophysiological examination of nerves was employed to detect the recovery of neurological functions after repair of nerve defect. At the 4th, 8th and 12th weeks after surgery, CMAP amplitudes in the GDNF group were [9.34 +/- 0.52] mV, [14.40 +/- 0.69] mV and [19.18 +/- 0.48] mV, significantly better than [0.39 +/- 0.07] mV, [1.44 +/- 0.41] mV and [9.27 +/- 0.40] in the control group [p<0.01]. Polylactic acid-trimethylene carbonate/GNDF slowrelease catheter can accelerate the functional recovery of injured nerves, thus promoting the regeneration efficiency of femoral nerves