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Objective:To annalyze the constitution rule and pathogenesis of Diabetic Peripheral Neuropathy (DPN) by data mining technology, so as to provide a theoretical reference for improving the therapeutic effect of TCM on treating DPN.Methods:343 cases of DPN patients dianosed with four TCM diagostic methods chosen from the Department of Endocrinology of Affiliated Hospital of Traditional Chinese Medicine of Guangzhou Medical University from January 2016 to January 2020 were collected. Statistical analysis software was used to conduct frequency analysis, correlation analysis and cluster analysis, and explained with TCM theory.Results:Among the 343 cases, 143 cases were male and 200 cases were female; Symptoms such as limb numbness, thirst, dry mouth, frequent urination at night, limb pain and so on occur more frequently; The main tongue images include thin white tongue, dark and red tongue or light red tongue; the main pulse conditions include string, fine and deep pulse. Numbness, thirst, dry mouth, thin and white fur, frequent nocturia and so on were closely related with other diseases. Four types of syndrome can be recombined by cluster analysis, which are blood stasis obstructing collaterals syndrome; kidney deficiency and blood stasis syndrome; stomach heat injuring Yin syndrome; spleen deficiency and phlegm dampness syndrome; heat toxin accumulation and syndrome of lingering pathogen due to deficient vital qi.Conclusion:The root of the disease is Yin deficiency with dry heat as the sympotom. Blood stasis runs through the whole process of the disease. The function of spleen and stomach should not be ignored in treatment.
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Objective:To investigate the effect of compound Sanggou granules on the activity of Fib, AT-Ⅲ, t-PA, PAI-1 and t-PA/ PAI-1 in hyperlipidemic rats. Methods: The hyperlipidemic rat model was established by feeding high fat diet to SD male rats. Sixty healthy SD rats were randomly divided into five groups: the normal diet control group, high fat control group, high dose drug group, low dose drug group and fluvastatin sodium group. Four weeks after the administration, the blood samples were withdrawn for the determination of the levels of blood lipid, Fib, A-Ⅲ, t-PA, PAI-1 and t-PA/ PAI-1. Results:Compared with those of the normal diet control group, the levels of TC, LDL-C, Fib and PAI-1 were increased and the levels of HDL-C, t-PA , AT-Ⅲand t-PA/ PAI-1 were decreased significantly (P<0. 01) in the high fat control group. Compared with those of the high fat control group, the levels of TC, LDL-C, PAI-1 and Fib were decreased(P<0. 01 or P<0. 05),and the levels of HDL-C, t-PA AT-Ⅲ and t-PA/PAI-1 were in-creased significantly in the high dose drug group (P<0. 05 or P<0. 01). The similar effects were shown in the fluvastatin sodium group with the stability of AT-Ⅲ. The levels of TC, LDL-C and PAI-1 were decreased and the levels of t-PA/PAI-1 were increased no-tably in the low dose drug group. Conclusion: Compound Sanggou granules exhibit hypolipidemic effect in hyperlipidemic rats, and can improve hypercoagulability and enhance anticoagulation and fibrinolytic activity in hyperlipidemic rats. Furthermore, compound Sanggou granules at high dose show the same effect as fluvastatin sodium, even in anticoagulation, the granules are superior to fluvasta-tin sodium.
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OBJECTIVE:To investigate the mechanism of litchi saponin in impr oving action of insulin resistance(IR)in rats with hyperlipemia-hepar adiposum.METHODS:The hyperlipemia-hepar adiposum was used to establish IR model of rats,the effects of litchi saponin,roglitazone and gliclazide on the index of fasting serum glucose(FSG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),tumor necrosis factor(TNF)-?,content of insulin,in?sulin sensitivity(ISI)and so on were observed in the model rats2hours after medication.RESULTS:Litchi saponin could sig?nificantly lower the level of FSG,TC,TG,contents of insulin and the concentration of TNF-?(P