RESUMEN
Introduction: Obesity increases triglyceride levels and decreases high-density lipoprotein concentrations in plasma. Artificial emulsions resembling lipidic plasma lipoprotein structures have been used to evaluate low-density lipoprotein metabolism. In grade III obesity, low density lipoprotein metabolism is poorly understood. Objective: To evaluate the kinetics with which a cholesterol-rich emulsion (called a low-density emulsion) binds to low-density lipoprotein receptors in a group of patients with grade III obesity by the fractional clearance rate. Methods: A low-density emulsion was labeled with [14C]-cholesterol ester and [³H]-triglycerides and injected intravenously into ten normolipidemic non-diabetic patients with grade III obesity [body mass index higher than 40 kg/m²] and into ten non-obese healthy controls. Blood samples were collected over 24 hours to determine the plasma decay curve and to calculate the fractional clearance rate. Results: There was no difference regarding plasma levels of total cholesterol or low-density lipoprotein cholesterol between the two groups. The fractional clearance rate of triglycerides was 0.086 ± 0.044 in the obese group and 0.122 ± 0.026 in the controls (p = 0.040), and the fractional clearance rate of cholesterol ester (h-1) was 0.052 ± 0.021 in the obese subjects and 0.058 ± 0.015 (p = 0.971) in the controls. Conclusion: Grade III obese subjects exhibited normal low-density lipoprotein removal from plasma as tested by the nanoemulsion method, but triglyceride removal was slower.
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , LDL-Colesterol/farmacocinética , Emulsiones Grasas Intravenosas/farmacocinética , Nanopartículas , Obesidad/sangre , Estudios de Casos y Controles , Emulsiones Grasas Intravenosas/administración & dosificación , Emulsiones Grasas Intravenosas/química , Nanopartículas/administración & dosificaciónRESUMEN
Paciente de 61 anos procurou atendimento médico com quadro clínico de infecção pulmonar. O estudo radiológico de tóraz revelou aneurisma de aorta descendente com comprometimento do arco aórtico. Ressalta-se a correção cirúrgica em uma única etapa, por meio de abordagem operatória não convencional, que possibilitou a correção total do aneurisma
Asunto(s)
Humanos , Masculino , Anciano , Aneurisma de la Aorta Torácica/cirugía , Aorta/anomalías , Aorta/cirugía , Circulación Extracorporea , Trastornos de la Voz/diagnóstico , Procedimientos Quirúrgicos Cardíacos/instrumentaciónRESUMEN
Emulsões artificiais semelhante as lipoproteínas plasmáticas são usadas na avaliação do metabolismo da lipoproteína de baixa densidade(LDL) porém em obesos grau III esse metabolismo lipídico ainda não é bem conhecido.O objetivo do estudo foi avaliar a cinética de uma emulsão rica em colesterol que se liga a receptores de LDL e mimetiza o comportamento do colesterol endógeno,em obesos grau III.A emulsão artificial de LDL foi marcada com colesterol éster-[14C] e triglicérides-[3H], injetada em 10 obesos grau III e 10 controles / Artificial emulsions of defined composition resembling the lipidic structure of the plasma lipoproteins have been used to evaluate low- density lipoprotein (LDL) metabolism.In morbid obesity,the LDL metabolism is poorly understood.The purpose of this study was to evaluate the kinetic of a cholesterol-rich emulsion that binds to the LDL receptors,called LDE, in a group of morbid obesity.LDE was labeled with [14C]-cholesteryl ester and [3H]-triglycerides and injected intravenously into 10 patients with morbid obesity and 10 controls...