Synthesis of some thiazole derivatives with anti fungal and anti microbial potential

The synthesis, structure elucidation and bio-activity of certain new 2-subtituted thiazole derivatives were reported. The newly prepared compounds were screened for their in vitro antibacterial and antifungal activities. The result revealed that almost compounds were active against fungi, 5 compounds were active against gram-positive bacteria. Meanwhile, 3 compounds had a remarkable both antibacterial and antifungal activities.

Synthesis and investigation and antifungal and antibacterial properties of some 2-amino thiazole derivatives

Condensing 2-amino-4-methyl-5-carbe thoxythiazole obtained from the cyclization process between thioure and ethylacetoacetate and oidine with some acylating agents to yield 9 new compounds of thiazole. All of them were screened for their invitro antibacterial and antifungal activities with respect to clotrimazol and cloramphenicol. The results showed that [2-(3,5-substuted salicylamido)-4-methyl-5-car-bethoxythiazole] compounds are active against gram-positive bacteria.