RESUMEN
Objectives: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman
Methods: We performed a cross-sectional review of culture-confirmed tuberculosis [TB] cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis
Results: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised [7.5%] of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern [3.5%]. Previous treatment for TB [odds ratio [OR] 14.81; 95% CI 3.09-70.98, p < 0.001], female gender [OR 3.85; 95% Cl 1.07-13.90, p < 0.039], and younger age [OR 6.80; 95% Cl 1.61-28.75, p < 0.009] were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis
Conclusions: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB
Asunto(s)
Humanos , Femenino , Recién Nacido , Lactante , Preescolar , Niño , Adolescente , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Centros de Atención Terciaria , Estudios Transversales , Factores de Riesgo , Modelos LogísticosRESUMEN
Hughes-Stovin syndrome is a very rare clinical entity characterized by pulmonary artery aneurysms and deep vein thrombosis [DVT]. Here we report the case of a 53-year-old man, admitted to Sultan Qaboos University Hospital, Muscat, Oman, with bilateral pulmonary artery aneurysms and lower-limb DVT who developed massive hemoptysis. He was managed successfully with high-dose steroids in combination with cyclophosphamide