Some hitherto unreported findings on the extragenital effects of progesterone in human females--a clinical study.

40 women suffering from 'dysfunctional uterine bleeding' (DUB) were treated by progesterone (P) and signs and symptoms of 'extragenital effects' of P were noted. In addition to the previous ones reported from this laboratory, a new crop of effects, which, as far as we are aware of, have never been reported in the literature, were found and included: (i) Changes in the frequency of EEG waves, (ii) changes in the ECG (iii) changes in psychoanalytical scoring. Further (iv) with most of the parametres, the intensity of the changes showed considerable waning with passage time, despite the fact that the subjects were still receiving P. Blood P levels similarly fell considerably in the initial phase of the therapy, but recovered to some extent afterwards, despite the continuance of P therapy.

A 5-year study of caesarean hysterectomy cases.

There were 53 cases where caesarean hysterectomy was done during the last 5 years at Eden Hospital, Calcutta. Majority of the cases were in the age group of 22-32 years and parity varied from 0 to 6. There were 54.71% cases which were due to rupture of previous caesarean section scar mostly lower uterine segment done in teaching institutions. Seventy per cent cases were booked. Only 8 babies survived following caesarean hysterectomy. Maternal mortality was nil. By good intranatal monitoring, more vigilance, performing less caesarean section and better health education one can lower the incidence of caesarean hysterectomy.