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1.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 850-854, 2020.
Artículo en Inglés | WPRIM | ID: wpr-881029

RESUMEN

Three new mycophenolic acid derivatives, penicacids E-G (1-3), together with three known analogues, mycophenolic acid (4), 4'-hydroxy-mycophenolic acid (5) and mycophenolic methyl ester (6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South China Sea marine sediment sample. The structures of compounds 1-3 were elucidated by HRMS, NMR, and Mosher's method. Among them, compounds 1 and 2 were the first examples of mycophenolic acid analogs with a double bond at C-3'/C-4' position. The cytotoxicity of 1-6 was evaluated against the HCT-116, BEL-7402, MGC-803, SH-SY5Y, HO-8910 and HL-60 cell lines, and compounds 4 and 6 showed potent cytotoxicity with IC

2.
Acta Pharmaceutica Sinica ; (12): 1275-1278, 2010.
Artículo en Inglés | WPRIM | ID: wpr-354527

RESUMEN

A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately.


Asunto(s)
Animales , Humanos , Ratones , Antineoplásicos , Química , Farmacología , Ascomicetos , Química , Línea Celular Tumoral , Supervivencia Celular , Hidroquinonas , Química , Farmacología , Concentración 50 Inhibidora , Células K562 , Leucemia P388 , Patología , Estructura Molecular
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