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1.
Braz. j. med. biol. res ; 43(3): 285-289, Mar. 2010. graf
Artículo en Inglés | LILACS | ID: lil-539722

RESUMEN

Serotonin has been implicated in the neurobiology of depressive and anxiety disorders, but little is known about its role in the modulation of basic emotional processing. The aim of this study was to determine the effect of the selective serotonin reuptake inhibitor, escitalopram, on the perception of facial emotional expressions. Twelve healthy male volunteers completed two experimental sessions each, in a randomized, balanced order, double-blind design. A single oral dose of escitalopram (10 mg) or placebo was administered 3 h before the task. Participants were presented to a task composed of six basic emotions (anger, disgust, fear, happiness, sadness, and surprise) that were morphed between neutral and each standard emotion in 10 percent steps. Escitalopram facilitated the recognition of sadness and inhibited the recognition of happiness in male, but not female faces. No drug effect on subjective measures was detected. These results confirm that serotonin modulates the recognition of emotional faces, and suggest that the gender of the face can have a role in this modulation. Further studies including female volunteers are needed.


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Adulto Joven , Citalopram/farmacología , Emoción Expresada/efectos de los fármacos , Expresión Facial , Reconocimiento Visual de Modelos/efectos de los fármacos , Inhibidores Selectivos de la Recaptación de Serotonina/farmacología , Estudios Cruzados , Método Doble Ciego , Adulto Joven
2.
Braz. j. med. biol. res ; 41(4): 333-341, Apr. 2008. ilus, tab
Artículo en Inglés | LILACS | ID: lil-479683

RESUMEN

Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains a high density of NMDA receptors and nNOS-expressing neurons suggesting the existence of an NMDA-NO transduction pathway which can be involved in the pathogenesis of affective disorders. We tested the hypothesis that nNOS expression is increased in the human hippocampus from affectively ill patients. Immunocytochemistry was used to demonstrate nNOS-expressing neurons in sections obtained from the Stanley Consortium postmortem brain collection from patients with major depression (MD, N = 15), bipolar disorder (BD, N = 15), and schizophrenia (N = 15) and from controls (N = 15). nNOS-immunoreactive (nNOS-IR) and Nissl-stained neurons were counted in entorhinal cortex, hippocampal CA1, CA2, CA3, and CA4 subfields, and subiculum. The numbers of Nissl-stained neurons were very similar in different diagnostic groups and correlated significantly with the number of nNOS-IR neurons. Both the MD and the BD groups had greater number of nNOS-IR neurons/400 µm² in CA1 (mean ± SEM: MD = 9.2 ± 0.6 and BD = 8.4 ± 0.6) and subiculum (BD = 6.7 ± 0.4) when compared to control group (6.6 ± 0.5) and this was significantly more marked in samples from the right hemisphere. These changes were specific to affective disorders since no changes were seen in the schizophrenic group (6.7 ± 0.8). The results support the current view of the NMDA-NO pathway as a target for the pathophysiology of affective disorders and antidepressant drug development.


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trastorno Bipolar/enzimología , Trastorno Depresivo Mayor/enzimología , Hipocampo/enzimología , Óxido Nítrico Sintasa de Tipo I/metabolismo , Esquizofrenia/enzimología , Trastorno Bipolar/fisiopatología , Estudios de Casos y Controles , Trastorno Depresivo Mayor/fisiopatología , Hipocampo/fisiopatología , Inmunohistoquímica , N-Metilaspartato/metabolismo , Esquizofrenia/fisiopatología , Transducción de Señal/fisiología
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