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1.
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 267-275, 2019.
Artículo en Inglés | WPRIM | ID: wpr-916015

RESUMEN

OBJECTIVES@#Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph nodes elicit an immune response to either wall off or create a favorable environment for homing of tumor cells. This immune response to tumor stimuli is visualized by recognizing various immunoreactive patterns exhibited by the lymph node. The present study aims to evaluate the role of immuno-morphologic patterns of the lymph node in neck dissection for cases of OSCC.@*MATERIALS AND METHODS@#Our retrospective study included 50 neck dissection cases of OSCC and a total of 1,078 lymph nodes. The grades of primary tumors with eight different immunoreactive patterns were compared. Vascularity and metastasis in lymph nodes were also evaluated.@*RESULTS@#The lymphocyte predominant pattern was the most common immunoreactive pattern found in 396 of 1,078 lymph nodes. Patterns of lymphocyte predominant (P=0.0005), sinus histiocytosis (P=0.0500), paracortical hyperplasia (P=0.0001), cortical hyperplasia (P=0.0001), and increased vascularity (P=0.0190) were significantly associated with tumor grade.@*CONCLUSION@#The present study adds to the understanding of lymph node immunoreactivity patterns and their correlation with tumor grade. We recommend further study of lymph node patterns for all sentinel lymph node biopsies and routine neck dissections for OSCCs.

2.
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 267-275, 2019.
Artículo en Inglés | WPRIM | ID: wpr-766350

RESUMEN

OBJECTIVES: Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph nodes elicit an immune response to either wall off or create a favorable environment for homing of tumor cells. This immune response to tumor stimuli is visualized by recognizing various immunoreactive patterns exhibited by the lymph node. The present study aims to evaluate the role of immuno-morphologic patterns of the lymph node in neck dissection for cases of OSCC. MATERIALS AND METHODS: Our retrospective study included 50 neck dissection cases of OSCC and a total of 1,078 lymph nodes. The grades of primary tumors with eight different immunoreactive patterns were compared. Vascularity and metastasis in lymph nodes were also evaluated. RESULTS: The lymphocyte predominant pattern was the most common immunoreactive pattern found in 396 of 1,078 lymph nodes. Patterns of lymphocyte predominant (P=0.0005), sinus histiocytosis (P=0.0500), paracortical hyperplasia (P=0.0001), cortical hyperplasia (P=0.0001), and increased vascularity (P=0.0190) were significantly associated with tumor grade. CONCLUSION: The present study adds to the understanding of lymph node immunoreactivity patterns and their correlation with tumor grade. We recommend further study of lymph node patterns for all sentinel lymph node biopsies and routine neck dissections for OSCCs.


Asunto(s)
Biopsia , Carcinoma de Células Escamosas , Células Epiteliales , Centro Germinal , Histiocitosis Sinusal , Hiperplasia , Ganglios Linfáticos , Metástasis Linfática , Linfocitos , Disección del Cuello , Cuello , Metástasis de la Neoplasia , Estudios Retrospectivos
3.
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2017; 27 (6): 373-375
en Inglés | IMEMR | ID: emr-188504

RESUMEN

An entity of bizarre plasma cells has been observed, containing spherical inclusions of immunoglobulins within the cytoplasm


These cells are termed as Mott cells and are believed to occur commonly in cases of chronic inflammation. Until now, they were reported to occur in systemic diseases, various hematolymphoid malignancies and in some syndromes; but their occurrence in chronic periapical infections of the oral cavity, given the paucity of available literature, raises questions about their obscure nature. In the present case report, a 24-year male presented with a draining sinus and periapical lesion involving the maxillary right incisors. After clinical and radiographic examination, an excisional biopsy sample of the periapical lesion was obtained. Histopathological examination revealed multiple bizarre Mott cells in the connective tissue stroma. The significance, nature or fate of these Mott cells is still unknown


Frequently overlooked or a chance occurrence, the presence of these multiple Mott cells in chronic inflammatory lesions of the oral cavity could be of some significance and demand increased awareness and further research


Asunto(s)
Humanos , Masculino , Adulto Joven , Enfermedades de la Boca , Células Plasmáticas , Inmunoglobulinas , Enfermedades del Tejido Conjuntivo , Inflamación
4.
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2016; 26 (7): 636-637
en Inglés | IMEMR | ID: emr-182365
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