Three cases of anti-TNF induced myositis and literature review / Três casos de miosite induzida pelo anti-TNF e revisão da literatura

Abstract Anti-tumor necrosis factor drugs are frequently preferred in the treatment of rheumatologic diseases and other inflammatory diseases. The development of myositis after using anti-tumor necrosis factor drugs is a rare clinical condition. Here we aimed to report cases who developed myositis after using anti-tumor necrosis factor drugs and review the current literature. We report two cases of rheumatoid arthritis and a case of ankylosing spondylitis developed idiopathic inflammatory myopathy following anti-tumor necrosis factor therapy. In conclusion, myositis could develop during anti-tumor necrosis factor therapy, so these patients should be evaluated carefully initially for myositis and should be closely monitored due to the potential for developing myositis in treatment process.

Resumo Os fármacos antifator de necrose tumoral (anti-TNF) são frequentemente preferidos no tratamento de doenças reumatológicas e outras doenças inflamatórias. O desenvolvimento de miosite após o uso de anti-FNT é uma condição clínica rara. Este estudo objetivou descrever casos de pacientes que desenvolveram miosite após o uso de anti-TNF e fazer uma revisão da literatura atual. Descrevem-se dois casos de artrite reumatoide (AR) e um caso de espondilite anquilosante (EA) que desenvolveram miopatia inflamatória idiopática após o tratamento com anti-TNF. Em conclusão, pode haver desenvolvimento de miosite durante o tratamento com anti-TNF, de modo que esses pacientes devem ser cuidadosamente avaliados inicialmente à procura de miosite e devem ser cuidadosamente monitorados em razão do potencial de desenvolvimento de miosite no processo de tratamento

Changes in some soil properties at different incubation periods after tobacco waste application.

In this study, changes in organic carbon (OC), basal soil respiration (BSR), nitrate nitrogen (NO3-N), electrical conductivity (EC) and aggregate stability (AS) of a clay loam soil due to tobacco waste (TOW) application were monitored for 240 days. After incorporating 5% TOW into soil according to oven dry weight basis, soil samples were incubated at field capacity for 20, 40, 80, 140 and 240 days under a greenhouse condition. TOW application significantly increased all soil properties over the control treatment. Soil OC and AS values had significant positive correlations each other and with the other soil properties. Soil OC, BSR and AS values significantly increased from 0.12%, 0.03 μg CO2-C g-1 dry soil 24 hr and 20.7% in control treatment to 1.13%, 3.7 μg CO2-C g-1 dry soil 24 hr and 54.4% in TOW treatment, respectively, in 20 days. While the highest NO3-N (1780 ppm) was found in 40 days, the highest EC (3.35 dS m-1) was in 240 days after TOW application. Disaggregation occurred in all treatments after 20 days of incubation due to probably the more substrate demands of microorganisms in soil.