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Braz. j. infect. dis ; 21(6): 606-612, Nov.-Dec. 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-888923

RESUMEN

ABSTRACT Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients' serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis. Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18 patients), and other infections (23 patients). The overall mortality was 13.3%. The time since diagnosis of HIV infection was shorter in the pneumocystosis group (4.94 years; p = 0.001) than for the other two groups of patients. The multivariate analysis showed that higher (1-3)-β-D-Glucan level (mean: 241 pg/mL) and lactate dehydrogenase (mean: 762 U/L) were associated with the diagnosis of pneumocystosis. Pneumocystosis was the aids-defining illness in 11 out of 16 newly diagnosed HIV-infected patients. Conclusion: In the era of antiretroviral therapy, PJP was still the most prevalent pulmonary infection and (1-3)-β-D-Glucan and lactate dehydrogenase may be suitable markers to help diagnosing pneumocystosis in our HIV population.


Asunto(s)
Humanos , Masculino , Femenino , Infecciones Oportunistas Relacionadas con el SIDA/diagnóstico , beta-Glucanos/sangre , L-Lactato Deshidrogenasa/sangre , Enfermedades Pulmonares Fúngicas/diagnóstico , Mananos/sangre , Biomarcadores/sangre , Estudios Transversales , Valor Predictivo de las Pruebas , Estudios Prospectivos , Análisis de Regresión , Sensibilidad y Especificidad , Infecciones Oportunistas Relacionadas con el SIDA/sangre , Enfermedades Pulmonares Fúngicas/sangre
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