RESUMEN
Objective To investigate the distribution of age and sex and the resistance of penicillin (p) and levofloxacin (LEV) among Streptococcus pneumoniae that were isolated from sputum.Methods The sputum specimens of our hospital from 2011 to 2013 were collected with the requirements of the third edition of National Clinical Laboratory Procedures,and 672 Streptococcus pneumoniae bacteria were isolated.Gram-Positive (GP) identification card was used to identify any doubt bacteria.LEV sensitivity was tested with Kirby-Bauer (KB) assay,and minimum inhibitory concentration (MIC) of P was tested with reagent strips (P-E test).Results A total of 672 Streptococcus pneumoniae bacteria was isolated in sputum.The number of age 0 to 6 years was 267 (39.73％),＞6 to 14 years was 62 (9.23％),＞ 14 to 60 years was 85 (12.65％),and ＞60 years was 258(38.39％) ; and isolating rates of age 0 to 6 years and ＞60 years were higher than other groups with statistically significant difference (P ＜0.01).The isolating rate of male (59.23％) was higher than female (40.77％) with a statistically significant difference (P ＜0.01).The sensitive rate of penicillin (p) to isolated strain was 73.78％ in 2011,71.32％ in 2012,and 53.50％ in 2013,respectively.MIC of isolated strain penicillin was increased year by year; however,LEV treated the isolated strain remain had a high sensitivity in first three years,the sensitivity of Streptococcus pneumoniae had no significant correlation between penicillin and LEV.Conclusions The resistance of penicillin was increased to streptococcus pneumoniae,patients who were infected by streptococcus pneumoniae and were allergic or resistant to penicillin can be considered to use an alternative therapy with LEV.