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Indian J Physiol Pharmacol ; 1991 Oct; 35(4): 232-6
Artículo en Inglés | IMSEAR | ID: sea-106369

RESUMEN

Nine normal men (mean age 27.6 yr) were exposed to continuous lower-body suction pressure (LBSP) of -20 to -50 mmHg (for 5 min at each level) on four different occasions after having consumed a single oral therapeutic dose of either diltiazem, nifedipine, verapamil, or a placebo, randomly, in a single blind manner. The suction was applied at 12.30 pm in all experiments, while the medications were administered in such a manner so that their expected peak plasma levels would have been achieved at the time of suction application. The cardiovascular reflex effects commenced at a pressure of -30 mmHg, and peaked at -50 mmHg. The increases in the heart rate for all treatments at -50 mmHg was statistically similar (about 16-20 beats/min). The systolic BP fell by about 9 mmHg for the placebo experiments, and this change was not different from the changes produced by the 3 Calcium channel blocker treatments. The diastolic BP increase was about 3 mmHg. The Cardiac index did not vary significantly. Our results suggest that the commonly used Ca++ channel blockers do not adversely affect orthostatic tolerance.


Asunto(s)
Adulto , Análisis de Varianza , Presión Sanguínea/efectos de los fármacos , Bloqueadores de los Canales de Calcio/farmacología , Fenómenos Fisiológicos Cardiovasculares , Sistema Cardiovascular/efectos de los fármacos , Electrocardiografía , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Presión Negativa de la Región Corporal Inferior , Masculino , Estimulación Física , Reflejo/efectos de los fármacos , Método Simple Ciego , Volumen Sistólico/efectos de los fármacos
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