RESUMEN
An experimental work was carried out in wistar rats to study the histopathological changes caused by different diets on the kidney and urinary bladder and to understand the risk of calcium oxalate crystallization. Both non-diabetic non-calculogenic and diabetic non-calculogenic rats were used for this study. The rats were fed on standard laboratory diet / diet low in vitamin A and diet rich in vitamin C for three months. At the end of the experiment the kidney and urinary bladder were excised and the tissues were processed for the histopathological study. The histopathological changes such as epithelial desquamation, interstitial inflammation and crystalline deposits of grade + were observed in the kidneys of rats on low vitamin A diet indicating the tendency of low vitamin A diet to promote lithogenesis. Amorphous debris and the birefringent crystalline deposits seen in the tubules along with metaplasia in the urinary bladder of rats on high vitamin C diet which indicate the tendency of high vitamin C diet to aggravate the calculogenic propensity.