RESUMEN
Background: Inflammation can be classified as either acute or chronic. NSAIDs are the most commonly prescribed drugs worldwide, and mostly have adverse effects. Lercanidipine a CCB of (DHPs) blocks the mediators of inflammation and has additional anti-inflammatory potential. Tanacetum parthenium (Feverfew) extracts have also shown its anti-inflammatory effects in experimental studies. It was decided to study anti-inflammatory effects of Lercanidipine and Tanacetum parthenium which was compared with Indomethacin. The present study was aimed to evaluate and compare the anti-inflammatory effect of lercanidipine and Tanacetum parthenium with Indomethacin in rats.Methods: The study was conducted in the department of Pharmacology UPUMS, Saifai after getting approval from IAEC.A total of 24 animals divided into 4 groups of six (n=6) animals each group were used, and the anti-inflammatory effects of both drugs were evaluated by Carrageenan-induced Paw Edema Model by digital Plethysmometer in rats, drug administration was with the same frequency.Results: The result of the present study had shown that lercanidipine produced anti-inflammatory effect compared to Indomethacin, while its efficacy in reducing paw edema was better at 1st hour, 48 and 72 hours while at 2nd hour and 3rd hour Indomethacin had better efficacy. Tanacetum parthenium also decreased paw edema at 2nd, 3rd, 48 and 72 hour while at 1st hour no effect was seen. However, at 72 hours, shown good efficacy compared to lercanidipine and Indomethacin.Conclusions: Lercanidipine could be a promising anti-inflammatory drug in reducing the inflammation and edema. However, herbal drug (Tanacetum parthenium) has shown anti- inflammatory efficacy when compared with Indomethacin. Both drugs were found safe during our study.
RESUMEN
Background: To study the changes in haemogram and coagulation profile in patients undergoing autologous and homologous blood transfusion and suitability of the technique of autologous blood transfusion in routine blood bank management.Methods: Patients who were waiting to undergo elective surgical procedures were randomly distributed in two groups, Group A: Autologous blood transfusion, with or without haemodilution: wherein pre-operative period a predicted volume of blood was collected and Group B: Homologous blood transfusion: where required blood was arranged from Blood Bank. The cardiovascular status, the haemogram and the coagulation profile were recorded at various stages.Results: Out of 240 patients registered only 43 could fulfil the basic requirements only 25 could be motivated in each group. In Group A cases were of age group 51-60 years while it was 41-50 years in Group B. Male:Female ratio was 2:1. 47 Units were retransfused to Group A patients, Group B cases received 45 blood transfusions. In Group A patients 8% cases showed mild hypotention and 1% showed mild hypersensitivity to Haemacel. In Group B, 40% cases showed transfusion reactions. Fall in Hb was lesser in Group A (2.4) on first and (1.7) on second postoperative day compared to Group B (3.3) on first and (2.7) on second postoperative day. The haematocrit levels declined more sharply after operation in Group B (7) rather than Group A (10.4).Conclusions: Advantage of avoiding transfusion reactions, major changes in blood parameters, entry of infections proves Autologous blood transfusion to be the safest, cost effective and easy form of transfusion therapy