Retinal toxicity of moxifloxacin injected intravitreally into rabbit eyes: A histological study

OBJECTIVE: To investigate the retinal toxicity of different doses of moxifloxacin after intravitreal injection into rabbit eyes. METHODS: Eight male rabbits were divided into four groups; 2 rabbits each were injected intravitreally with moxifloxacin 48 ug, 240 ug, 480 ug, and normal saline solution. Ocular toxicity was assessed at day 3 and day 7 by slit-lamp biomicroscopy, ophthalmoscopy, and histology. RESULTS: All eyes showed no abnormalities on histologic evaluation. No relevant complications were found during slit-lamp biomicroscopy and indirect ophthalmoscopy. CONCLUSION: Intravitreal injection of 480 ug or less of moxifloxacin did not produce retinal toxicity histologically in rabbit eyes.