Chromatographic Determination of the Absolute Configuration in Sanjoinine A That Increases Nitric Oxide Production

A chiral derivatization strategy with phenylglycine methyl ester (PGME) was employed to develop a straightforward method to determine the absolute configurations of N,N-dimethyl amino acids. The PGME derivatives were analyzed using liquid chromatography-mass spectrometry to identify the absolute configurations of various N,N-dimethyl amino acids based on their elution time and order. The established method was applied to assign the absolute configuration of the N,N-dimethyl phenylalanine in sanjoinine A (4), a cyclopeptide alkaloid isolated from Zizyphi Spinosi Semen widely used as herbal medicine for insomnia. Sanjoinine A displayed production of nitric oxide (NO) in LPS-activated RAW 264.7 cells.

New Meroterpenoids from a Penicillium sp. Fungus

Two meroterpenoids (1 and 2) along with twelve known compounds (3 – 14) were isolated from the culture broth of a Penicillium sp. fungus collected from Chuja-do, Korea. Based on the results of a combination of spectroscopic analyses, the new compounds, preaustinoids E (1) and F (2), were determined to be epimeric austin-type penta-cyclic lactones.

The effect of xerostomia on perceived oral health among Hansen's people wearing dentures / 나학회지

OBJECTIVE: This study examined xerostomia of Hansen's people wearing dentures, their perceived oral health as well as how their general characteristics and xerostomia affected their perceived oral health. METHODS: total of 100 subjects, who were 65 years or older and used in the sorokdo national hospital, were enrolled in this study. A survey and oral examination were carried out through a separate interview from July 1 through to July 30, 2015. A x2-test, t-test, one-way ANOVA, and linear regression analysis were used to analyze the data using the SPSS program. RESULTS: The number of natural teeth in the group of people under and over 74 was 9.92 and 7.01, respectively. The percentage of elderly people who were complete and partial dentures was 45,9% and 39.4% respectively. 48.2% and 31.1% of the elderly adults perceived their oral health to be moderate and poor, respectively. Regarding xerostomia, the subjects achieved a mean of 7.87 out of a maximum 12 points. Moreoverthose who were older and had fewer natural teeth felt that their xerostomia was more severe. The subjects xerostomia and perceived general health had a significant impact on their perceived oral health. CONCLUSIONS: These results highlight the need for oral health programs to help hansen's people retain more of their natural teeth.

Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.

A New Sesterterpene from the Korean Sarcotragus sp. Sponge

Sarcotragin C (1), a new sesterterpene metabolite was isolated from a Sarcotragus sp. sponge collected from Chuja Island, Korea. On the basis of the combined spectroscopic analyses, the structure of this compound was determined to be a linear norsesterterpene containing a leucine-derived gamma-lactam moiety. This compound exhibited moderate cytotoxicity against K562 and A549 cell-lines.

Association between perception of dry mouth and pre and post-wearing denture satisfaction in the Hansen people / 나학회지

OBJECTIVES: This study investigated on the severity of dry mouth in the hansen people and the association between dry mouth(low, moderate and high) with pre and post wearing denture satisfaction. METHODS: Data were obtained from a cross-sectional survey of 104 hansen people(mean age=69.3). Data were collected by means of a personal interview from April 30 through to Jane 20, 2014. Pre and post wearing denture satisfaction was measured by the 24-items and dry mouth was measured by the 4-items. The data was analysed with t-test, One-way ANOVA, and Logistic regression using the SPSS program. RESULTS: Regarding perception of dry mouth, the subjects achieved a mean of 6.13 out of a maximum 12 points. Scores were categorised as high(8~12), medium(5~7) or low(1~4) and the proportion were 24.5%(9.56), 42.2%(5.81) and 33.3%(4.00) respectively. Those who were older and had fewer natural teeth felt that their perception of dry mouth was more severe. A logistic regression analysis showed that the subjects perception of dry mouth had a significant impact on their gender (OR=2.73), comfort (OR=0.21), aesthetic appreciation (OR=7.56) satisfaction. CONCLUSIONS: Based on the findings, the perception of dry mouth has a significant and negative impact on denture satisfaction. These results suggest that oral health promotion should be considered various factors related dry mouth in the elderly with removable denture.

The effectiveness of maintenance care by non-surgical treatment on the periodontal disease in the people affected by leposy / 나학회지

BACKGROUND & OBJECTIVE: The purpose of this study is to prove the effectiveness of professional maintenance care to the periodontal disease by non-surgical approach with the toothpick method to improve the periodontal health. METHODS: The patients of this study were composed of 46 patients( 18 men and 28 women), suffering from chronic adult periodontitis, who had visited the department of dental clinic center. All of the subjects were over 50years old and be treated just by non-surgical method. Professional maintenance care using the toothpick method was performed every 3 months, and evaluations were also done after 1, 2, and 3 year-professional maintenance care based on the indices such as plaque index(O' Leary index), periodontal probing pocket depth, bleeding on probing, tooth mobility, the number of tooth loss, and the rate of tooth loss representing the state of periodontal health. RESULTS: 1. The longer the maintenance care, the more the effectiveness of controlling plaque. The rate of decrease in the dental plaque index was 1.5%, 4.2%, and 6.5% in 1, 2, and 3 year maintenance groups respectively(P>0.05). 2. The periodontal pocket depth decreased depends on the severity of periodontal pocket depth in all groups the maintenance years(P0.05). 4. Tooth mobility has decreased in the maintenance years, but did not show any difference statistically(P>0.05). 5. The number and the rate of tooth loss among the patients of 1year-maintenance group was 0.38, 1.44% respectively and that of 3 year-maintenance group was 0.44, 1.73% each. CONCLUSION: The results of this study mentioned above suggest that professional maintenance care should be operated effectively to prevent and to maintain the periodontal disease systematically on the purpose of proving the quality of life, and that it could be applied to the medical insurance system in other to try to make the most of the adult oral health care positively.

A study on the design of the removable partial denture in the identical master cast of the leprosy patient / 나학회지

The upper and the lower master models of Class II mod.1 by the Kennedy of classification were duplicated to the dentists in the dental clinic Suncheon, and the status of the surveying procedure, the form and type of the major connector, the form and type of the direct retainer, the location and status of the indirect retainer, and the modification of abutment were surveyed and analyzed and were compared to the principles of the design rationale of the removable partial denture to evaluate whether or not each component of the removable partial denture framework designed by the dentists. The analyzed results were as follows: 1. The status with or without the surveying procedure was showed 7 cases(10.29%) and 61 cases(89.71%) respectively. 2. Single palatal strap, A-P bar, broad palatal plate, complete coverage palatal major connector, single palatal bar, U-shaped palatal connector, and the others without drawing of the major connector were 27 cases (38.57%), 25 cases(35.71%), 5 cases(7.01%), 4 cases(5.71%), 2 cases (2.86%), 1 cases(1.43%), 6 cases(8.57%) respectively in the design patterns of the maxillary major connectors, and lingual bar, linguoplate, and others without drawing of the major connector were 55 cases(80.88%), 11 cases(16.18%), 2 cases(2.84%), respectively in the pattern of the mandibular major connectors. 3. The direct retainer designed to the 1st bicuspid of the upper left and the lower right adjacent to the free-end edentulous area was that the design of bar clasp was 67.41% in the highest rate and that of Akers clasp was 23.36%. 4. The direct retainer designed to the 1st bicuspid of the upper right and the lower left was that the of Akers clasp was 56.62% in the highest rate and that of bar clasp was 33.82%. 5. The mesial rests of the 1st bicuspid of the upper left and the lower right adjacent to the free-end edentulous area were 77.46%, 66.20% respectively and the distal rests and mesial rests of the 1st bicuspid of the upper left and the lower right were 58.82%, 55.71%, 38.24%, 38.57% respectively and the mesial rests of the 2nd molar of the upper right and the lower left were 95.71%, 95.65% respectively, viewed from the location of the occlusal rest seat. 6. The cases without the design of the indirect retainer were 51.47% in the upper and the lower master models respectively. 7. The modification of abutments(surveyed crown) of upper and lower teeth were 8.82%, 8.82% respectively.

A Study on the fabrication request for the removable partial denture framework / 나학회지

The purpose of this study was to investgate and evaluate whether the recording information contained in the work authorization was performed properly and master casts were designed accurately according to the rationale and principles of the removable partial denture when the work authorization and the master casts were sent to the dental framework. the accurate recording of the work authorization sent to dental laboratory in Hwasun for removable partial denture framework, the normal form of the occlusal rest guiding plan of the surveyed crown using the surveyor, the location analysis of the occlusal rest seat, the design patten of the maxillary and mandibulary major connectors, the use of the surveyor on the master cast, the status of the secondary impression taken in the distal extension edentulous areas were investigated for this study. The following results were obtained : 1. In the status of the occlusal rest seat prepared in the abutment, the occlusal rest seat with normal form was 81.25%, 95.45%, that without form was 6.25%, 0.00%, respectively in Class I and Class II on the maxillary cast and the occlusal rest seat with normal form was 76.92%, 95.45%, that without form was 7.69%, 0.00% respectively in Class I and Class II on the mandibular cast. 2. In the status of the guiding plan, the guiding plan with the normal form was 79.17%, 86.36% that with abnormal form was 20.84%, 13.64% respectively in Class I and Class II on the maxillary cast and the guiding plan with normal form was 79.49%, 77.27%, that with abnormal form was 20.51%, 22.73% respectively in Class I and Class II on the mandibular cast. 3. The abutment splinting in the distal extension removable partial denture was 20.78%, 27.27%, respectively in Class I and Class II on the maxillary cast and was 25.64%, 13.64% respectively in Class I and Class II on the mandibular cast. 4. The location and form of the major connector delineated on the maxillary and mandibular master cast was 95.83%, 98.41% respectively. 5. The delineation and recording on the work authorization was incomplete as group II(73.33%), group I(14.07%), group III(12.59%) and group IV (0.00%) in investigating the contents of the work authorization. 6. Aker's clasp of the types of the direct retainer was nots used 72.22%, 74.60%, in the maxillary and mandibular casts respectively. 7. The location of the indirect retainer delineated on the maxillary and mandibular master cast was 51.43%, 50.82% respectively. 8. The types of metal used were mostly Cr-Co non-precious metal alloy and the cases using color coding on the drawing paper of work authorization were not observed. 9. The cases taking secondary impression in the distal extension removable partial denture were 45.71%, 52.46% respectively in the maxillary and mandibular master cast. 10. The delineation of tripoding or reference line on the master cast was not observed in surveying procedure.

Subjective oral health perception of Hansen's disease in Sorokdo / 나학회지

The purpose of this study was to examine subjective oral health perception of Hansen's disease in Sorokdo. And the relationship of four categories (chewing ability, intraoral pain, intraoral othersysptom, and communication ability and social relationship) with clinical index was tried to clarify. The 460 subjects of Hansen's disease in Sorokdo was selected for oral examination and survey. The results are as follows: 1. 73.1% of Hansen's disease in Sorokdo recognized that their oral health is unwell. 2. 70% of total population recognized that they have limitation about chewing function, Especially, 35.9% of Hansen's disease feels chewing difficulty for standard foodstuffs as rice cake. 3. In intraoral pain, painful tooth was 76.3%, sensitive tooth was 43.2%. and temporomandiblular joint pain was 15.2%. 4. In intraoral other symptoms, tooth mobility was 71.3%, food impaction was 78.9% gingiavl bleeding was 96.8%, xerostomia was 62.8%, and halitosis was 84.2%. 5. 21.5% of Hansen's disease in Sorokdo has communication difficulty by teeth or denture problem, and 39.2% of them avoid relationship with other people.

Oral Infection Diagnosis and Treatment in Hansen's Patient / 나학회지

Dental infection which has been harmful to human for a long time occurs when the balance of three factors; host, environment and source of infection are broken and occurs especially when the balance of the resistance of the host and the toxin of bacteria are collapsed. Though dental-origin infection causes severe pain, it is commonly localized in gingiva, pulp and the surface of alveolar bone and as the decrease of its prevalence due to the development of antibiotics and the ease of treatment by a simple aids, there are no case that proper caution are made for the infection. Expecially in case of patient with infectious Hansen's disease(leprosy), as they have many other medical diseases, dental disease are mostly passed by. As oromaxillary infection can end up to death, though it is hard to treat a severly progressed myofascial space infection, general understanding about the reason, the pattern of spreading, treatment, prevention of it should be needed to make actual management in the situation of an doubtless developing of infection in patient treatment and situation of suspicious development of early myofascial space infection. Since last 5 years, 36% of the patients were hospitalized due to their dental infection and consistent advertising and treatment resulted in a gradual decrease of it.

Periodontitis and Periodontal treatment of Hansen's Patients in National Sorokdo Hospital (Case Report) / 나학회지

The purposes of this case report(8 case) were to investigate the oral health periodontal conditions (CPITN 1 : 3, CPITN 2 : 182, CPITN 3 : 528) and prevent natural teeth through periodontal treatment(non-surgical periodontal treatment and surgical periodontal treatment) of patients who have Hansen's disease, which is an infectious periodontitis. Operative method of periodontal treatment are scaling, root planning, gingivectomy, partial flap, full flap.

Analysis of Oral State of Hansen's Patients and Denture fabrication for Pre-Prothodontic Oro-maxillofacial minor surgury / 나학회지

The purposes of this study were to investigate the oral health care conditions of patients who have Leprous disease, which is an infectious disease(Dental caries: DMF rate and DMFT rate, and Periodontal conditions: CPITN0, CPITN1 CPITN2 CPITN3 ) and the satisfaction of use of denture fabrication related to general, functional and esthetic factors among dental patients for pre-Prothodontic Oro-maxillofacial minor surgury in National sorokdo hospital. The objects for this study were 754patients(male: 453, female: 301, 60-69ages: 340, 70-79ages: 414)treated in the oral health center among Leprous disease patients with gingivitis and periodontal disease, residents in the Sorokdo from 2003, January to 2005, September. 1. The results of Dental caries investigated that the number of 60-80year-old patients group that DMF rate was 99.2% of them, DMFT rate 59.2% 2. The results of periodontal conditios investigated that the number of 60-69year-old patients group were Community Periodontal treatment need index(CPITN)0: 15, CPITN1: 2, CPITN2: 66, CPITN3: 257, and 70-79year-old patients group were CPITN0: 27, CPITN1: 1, CPITN2: 116, CPITN3: 271 (Community Periodontal treatment need index(CPITN)0 of patients who have Leprous disease means anodontia states) 3. Dental fabrication patients for pre-Prothodontic Oro-maxillofacial minor surgury have operated Lower lip reconstruction, Hypergingivotomy, Flap, Alveoloplasty, Tours ostotomy and Apicoectomny

Analysis of Satisfaction with Removal Dental Prosthesis among Hansen`s Patients / 나학회지

The purposes of this study were to investigate the satisfaction of use of removable denture elated to general, functional and esthetic factors among dental patients in national sorokdo hospital, and to establish the structure relationships of dental treatment satisfaction. Two hundred fifty hansen`s patients who consented with this survey were selected and examined their oral status. Satisfaction degree was estimated by means of self-developed questionarires, filled out by face-to-face interview. Collected data were analyzed by t-tast The obtained results were as follow : 1. The satisfaction degree of four subscales was highest in esthetic actor (3.17+/-0.36), denture retention factor(3.10+/-0.60), general treatment satisfaction factor(2.94+/-0.56), and masticatory function factor (2.90+/-0.68) in descending order. It was appeared that patients was generally satisfied with all four factor. 2. On the comparison between proportion of denture satisfaction and satisfactio 02n of subscales, as the satisfaction of general treatment, masticatory function and denture retention were increased, the proportion of denture satisfaction of esthetic function and proportion of denture satisfaction. 3. The masticatiory function factor, denture retention factor and genernal satisfaction of treatment factor were directly affected on the denture satisfaction, but esthetic factor was affected indirectly on the denture satisfaction as a result of path analysis

An analytical on the periodontal conditions and treatment in leprous patients / 나학회지

The purpose of this study was to investigate the oral health periodontal conditions (CPITN(0), CPITN(1) CPITN(2) CPITN(3)) and periodontal treatment (non-surgical periodontal treatment and surgical periodontal treatment) of patients who have leprous disease. The objects for this study were 754patients (male: 453, female: 301, 60-69ages: 340, 70-79ages: 414) treated in the oral health center among Leprous disease patients with gingivitis and periodontal disease, residents in the Sirocco from 2003, May 1st to 2005, April 30th. The subdivided result carrying out periodontal conditions and treatment were as follows: 1. The results of periodontal conditions investigated that the number of 60-69year-old patients group were Community Periodontal treatment need index (CPITN)0: 15, CPITN1: 2, CPITN2: 66, CPITN3: 257, and 70-79year-old patients group were CPITN0: 27, CPITN1: 1, CPITN2: 116, CPITN3: 271 (Community Periodontal treatment need index(CPITN)0 of patients who have Leprous disease means exodontias states) 2. The results of periodontal treatment investigated that Non surgical periodontal treatment 25%, Surgical periodontal treatment 70%

An analytical on the dental cares in leprous patients / 나학회지

The purpose of this study was to investigate the oral health care conditions of patients who have Leprous disease, which is an infectious disease fixed for the third-class by law, to understand oral health care methods and effects of infectious disease patient, and to analyse those methods and effects in order to apply them to the national oral health occupation baseline data for utilizing continuous oral health occupation and to the treatment for handicapped person. he objects for this study were 7,491 patients(male:4,511, female:2,980) treated in the oral health center among Leprous disease patients, residents in the Sorokdo from 1995, May 1st to 1999, April 30th. We divided them into the first, second, third preventive care group according to the year by preventive classification of oral disease, analysed oral health statistics, classification according to the sex, age, practice, and each consultation hours. The subdivided results carrying out continuous oral health care system for four years were as follows: 1. The distribution for the age indicated that the number of 70-79 year-old patients group was the most, 2,169 and that of 60-69 year-old patients group was the second, 2,406. 2. All the number of consultation hours was 13,454. The consultation hours of first preventive care group were 1,359, 10.1% of them (male:812 female:547), the second group 3,942, 29.3%(male:2,103 female:1,839), the third 8,153, 60.6%(male:5,524 female:2,629) 3. The results of oral health care conditions indicated that DMF rate was 99.2% of them, DMFT rate 59.2%, DMF index 18.9, DT rate 2.6%, FT rate 7.4%, MT rate 49.1%, CPITN0 5%, CPITN10%, CPITN2 24%, CPITN3 71%. 4. It was analysed that the number of patients treated with continuous bridgework was 60 and that the number of patients wearing complete denture and partial denture was 290.