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1.
Journal of Veterinary Science ; : 487-497, 2017.
Artículo en Inglés | WPRIM | ID: wpr-16835

RESUMEN

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several mutations have been associated with the disease process. In particular, mutant superoxide dismutase 1 (SOD1) protein causes oxidative stress by activating glia cells and contributes to motor neuron degeneration. KCHO-1, a novel herbal combination compound, contains 30% ethanol and the extracts of nine herbs that have been commonly used in traditional medicine to prevent fatigue or inflammation. In this study, we investigated whether KCHO-1 administration could reduce oxidative stress in an ALS model. KCHO-1 administered to ALS model mice improved motor function and delayed disease onset. Furthermore, KCHO-1 administration reduced oxidative stress through gp91(phox) and the MAPK pathway in both classically activated microglia and the spinal cord of hSOD1(G93A) transgenic mice. The results suggest that KCHO-1 can function as an effective therapeutic agent for ALS by reducing oxidative stress.


Asunto(s)
Animales , Ratones , Esclerosis Amiotrófica Lateral , Sistema Nervioso Central , Etanol , Fatiga , Inflamación , Medicina Tradicional , Ratones Transgénicos , Microglía , Modelos Animales , Neuronas Motoras , Enfermedades Neurodegenerativas , Neuroglía , Estrés Oxidativo , Médula Espinal , Superóxido Dismutasa
2.
Korean Journal of Nephrology ; : 54-61, 1991.
Artículo en Coreano | WPRIM | ID: wpr-50063

RESUMEN

No abstract available.


Asunto(s)
Humanos , Sistema Nervioso Autónomo , Fallo Renal Crónico
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