correlation between the glycated hemoglobin [HbA1c] in nondiabetics and cardiovascular risk factors

This study aimed to discuss the relativity between the glycated hemoglobin [HbA1c] in non-diabetics and cardiovascular risk factors and definite the significance of predicting the cardiovascular risk factors through crosssectional research method. There were 2007 cases volunteers [including 650 cases of male, 1357 cases of female] from city community with complete information involved in the research of diabetes. The value of HbA1c 6.5% was set as the diagnose boundary of the diabetes. Differences were considered to be statistically significant at P<0.05. Hypertension, dyslipidemi, being overweight or obesity, age [male was over 45 years old and female was over 55 years old.], HbA1c 6.0% and fasting blood glucose [FBG] 6.1mmol/L were regarded as cardiovascular risk factors. Then we analyzed the number of risk factors for individuals in different HbA1c groups. Meanwhile, patients were grouped into zero, one, two, three, four or more groups with reference to the number of risk factors they had in order to compare the values of risk factors in different groups through Logistic regression. The results showed that [1] For those people who had no less than three risk factors, the frequency of risk factors was on the rise with the increase of HbA1c levels. [2] The value of HbA1c in different groups of risk factors rose with the increasing number of risk factors. There was a significant difference [P<0.001] between groups. [3] The Regression analysis showed that there was a stronger correlation between HbA1c levels and impaired glucose tolerance [IGT], fasting blood glucose[FBG] rather than age. So Non -diabetics whose HbA1c levels ranged from 6.0% to 6.5% were at high risk of cardiovascular risk factors. HbA1c levels, which can be a prediction index for cardiovascular risk factors dependent from other cardiovascular risk factors for non-diabetics, and it were highly relevant with impaired glucose tolerance [IGT] and impaired fasting blood glucose [FBG]

Effect of amiodarone and metoprolol on platelet activation, fibrinolytic activity and vasoactive mediators in acute myocardial infarction in rabbits / 中国病理生理杂志

AIM: To explore the significance of platelet activation, fibrinolytic activity and the changes of vasoactive mediators in acute myocardial infarction in rabbits and the intervention of amiodarone and metoprolol. METHODS: Fifty New Zealand white rabbits were randomly assigned to five groups, ten for each. Group Ⅰ: sham group, group Ⅱ: acute myocardial infarction(AMI) group, group Ⅲ: AMI and lidocaine group, group Ⅳ: AMI and amiodarone group, group Ⅴ: AMI and metoprolol group.The middle point of left ventricular coronary artery was ligated (groupⅡ,Ⅲ, Ⅳ and Ⅴ ) or a sham ligation(group Ⅰ). Four hours later, blood was collected for measuring plasma concentration of TXB 2, 6-Keto-PGF 1?, ET, NO, plasma activity of t-Pa and PAI.After that, the heart was taken out to evaluate the infarction size(IS). RESULTS: Plasma concentration of TXB 2, ET, NO and plasma activity of PAI were significantly higher in groupⅡ,Ⅲ, Ⅳ and Ⅴ than those in group Ⅰ(P0.05).Compared to group Ⅱ, plasma concentration of ET, NO and PAI activity were significantly decresed (P