Uma nova técnica para avaliar a lesão endotelial na arteriosclerose / A new technique to evaluate the endotelium lesion in atheroesclerosis

Os autores propõem uma nova técnica para avaliar a relação entre infecção e aterosclerose pela coleta de sangue da artéria coronária depois da lesão ou do seio coronariano em casos de insuficiência coronariana aguda durante a angioplastia, buscando bactérias, vírus e fragmentos de DNA virais

Valor do peptídeo natriurético do tipo B no diagnóstico de insuficiência cardíaca congestiva em pacientes atendidos com dispnéia na unidade de emergência / The role of B-type natriuretic peptide in the diagnosis of congestive heart failure in patients presenting to an emergency department with dyspnea

OBJECTIVE: To determine the utility of B-type natriuretic peptide (BNP) in the diagnosis of congestive heart failure (CHF) in patients presenting with dyspnea to an emergency department (ED). METHODS: Seventy patients presenting with dyspnea to an ED from April to July 2001 were included in the study. Mean age was 72±16 years and 33 (47 percent) were male. BNP was measured in all patients at the moment of admission to the ED. Emergency-care physicians, blinded to BNP values, were required to assign a probable initial diagnosis. A cardiologist retrospectively reviewed the data (blinded to BNP measurements) and assigned a definite diagnosis, which was considered the gold standard for assessing the diagnostic performance of BNP. RESULTS: The mean BNP concentration was higher in patients with CHF (n=36) than in those with other diagnoses (990±550 vs 80±67 pg/mL, p<0.0001). Patients with systolic dysfunction had higher BNP levels than those with preserved systolic function (1,180±641 vs 753±437 pg/mL, p=0.03). At a blood concentration of 200 pg/mL, BNP showed a sensitivity of 100 percent, specificity of 97.1 percent, positive predictive value of 97.3 percent, and negative predictive value of 100 percent. The application of BNP could have potentially corrected all 16 cases in which the diagnosis was missed by the emergency department physician. CONCLUSION: BNP measurement is a useful tool in the diagnosis of CHF in patients presenting to the ED with dyspnea