Development of fast release mebeverine hydrochloride tablets

The drug release from five commercial br and s of mebeverine hydrochloride tablets was tested. The results revealed the presence of large interbr and and intrabatch differences. These differences in drug release were attributed mainly to the physical behavior of the raw material during the production processes. Mebeverine hydrochloride crystals prepared from benzene were used for the preparation of four tablet formulations by the direct compression technique. The release of the drug from formulated tablets was superior to most of the commercially available br and s