RESUMEN
The interaction between rofecoxib [ROF], an analgesic antiinflammatory drug, with beta-cyclodextrin and HP-beta-cyclodextrin was evaluated in aqueous environment and in solid state. The solubility of ROF with beta-CyD and HP-beta-CyD in aqueous solution was determined and the stability constants were calculated from the phase solubility studies at different temperatures. Binary systems of ROF with the investigated CyDs were prepared by co-grinding and solvent evaporation methods. The formation of inclusion complexes with beta-CyD and HP-beta-CyD in the solid state was investigated by differential scanning calorimetery, infrared spectroscopy and X-ray diffractometry. Dissolution rate of ROF binary systems was determined and compared with those of the physical mixture and the pure drug. It was found that the solubility of ROF increased as a function of both CyDs concentration and temperature showing an AL- type diagram indicating the formation of 1: 1 stoichiometric inclusion complexes. The apparent association constants were found to be 104.45 M-1 and 121.65 M-1 for beta-CyD and HP-beta-CyD; respectively. Co-grinding method led to enhancement of ROF dissolution rate in comparison to the other preparation methods. The in vitro dissolution rate of ROF at pH 7.4 could be ranked in the following order: ground mixture, coevaporate, physical mixture and pure drug. Ground mixture of ROF with HP- beta-CyD and betaCyD has a t50% = 7 min and 50 min, respectively
RESUMEN
V irrational normal coordinate analysis has been made for the SCCl2 molecule in both the ground and excited electronic states with C2vand Cs molecular symmetries, respectively. Results indicate that both C=S and C-C1 bonds are weakened in the excited electronic states. The C=S force constant amounted to 465 and 335 Nm[-1] in the ground and excited electronic states, respectively. The corresponding C-C1 force constants were 293 and 135 Nm[-1]. The calculated bond orders amounted to 0.95 and 0.764 for the C=S bond and 0.722 and 0.461 for the C-C1 bond in the ground and excited electronic states of SCCl2, respectively