Histopathological study on endometrium of women with postmenopausal bleeding in upper Egypt

This work was done to study the variant histopathological pictures of the endometrium of postmenopausal bleeding [PMB] patients. 150 endometrial specimens of PMB cases were received at the Gynecological Laboratory of Assiut University Hospital. They were routinely processed, stained by hematoxylin and eosin and examined. PMB causes were classified into organic and non-organic. The former was 41% while, the later was 59% of the cases. The most common organic cause of bleeding was endometrial hyperplasia [36%]. Proliferative endometrium was the commonest cause of non-organic PMB [31%]. Endometrial carcinoma was found in 4% of the cases. The majority of PMB patients were in age ranging from 45 to 50 years [55%]

Immunohistochemical detection of IgG, IgA, IgM and C3 complement in thyroid lesions

The present work focused on the detection of immunoglobulins IgG, IgA, IgM and C3 complement in a wide variety of thyroid diseases as well as in normal thyroid tissue to evaluate the immunologic nature of these lesions. The study was encountered on 111 thyroid specimens selected from the biopsies received at the Pathology Laboratory over a period of 5 years. Formalin fixed paraffin embedded sections were prepared and stained by H and E and immunoperoxidase technique. IgG, IgA and IgM were detected in varying degrees in all types of thyroid lesions and also in normal thyroid tissue. While, positivity for C3 complement was detected in [6/10] cases of toxic nodular goiter, all cases of cretinism with goiter 8, in 11 out of 13 cases of Graves disease, in 14 out of 19 cases of thyroiditis and in 10 out of 16 cases of papillary carcinoma of the thyroid gland. However, no C3 complement could be detected in normal thyroid tissue, in cases of simple goiter, in all cases of thyroid adenoma and in all cases of follicular, anaplastic and medullary carcinoma examined. Results indicated that immunoglobulins are not predictors for diagnosis of autoimmunity in thyroid diseases, but are best considered as indicators for the gland activity. However, C3 and immunoglobulins may be used as useful markers for the diagnosis of papillary carcinoma and its follicular variant from follicular carcinoma