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Assiut Veterinary Medical Journal. 2006; 52 (108): 211-230
en Inglés | IMEMR | ID: emr-135532

RESUMEN

The humoral and cellular immune response in guinea pigs vaccinated with Rev-1 vaccine and simultaneously treated with antibiotics [oxytetracycline, streptomycin or enrofloxacin] or 4 weeks post-vaccination were evaluated in the present study. Groups vaccinated and simultaneously treated with oxytetracycline or 4 weeks post-vaccination showed delayed or abrupt reduction respectively in antibody production, lymphocyte transformation, phagocytic percent and intra-cellular killing one week post administration of this antibiotic while groups vaccinated and simultaneously treated with streptomycin or 4 weeks postúvaccination showed abrupt reduction in antibody titer and moderate reduction in phagocytic percent, intra-cellular killing and lymphocyte transformation. Treatment by enrofloxacin simultaneously with Brucella melitensis Rev-1 vaccine or at peak of vaccination [4 weeks postúvaccination] cause non-significant variation in both humoral and cellular immune response. Therefore oxytetracycline and streptomycin should not be recommended for animal treatment during exposure to Brucella melitensis Rev-1 vaccine. In contrast enrofloxacin exhibited a satisfactory margin of safety upon the humoral and cellular immune responses to Brucella melitensis Rev-1 vaccine


Asunto(s)
Animales , Vacunas Bacterianas/inmunología , Antibacterianos , Brucelosis/terapia
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