Synthesis of 1,3,4-thiadiazen [5,6-c], imidazole [4,5-c] and pyrano [4,3-b] quinoline derivatives

TN continuation of our work to find new flat and more active quinoline derivatives with lower side effects, we synthesized some quinoline-fused-heterocycles which possess biological activities such as : thiadiazene; cardiac stimulant in cats[1], imidazole; an inotropic, bronchodilator and phosphodiestrase inhibitor[1] and pyrane; which has antiasthmatic effect [2]. In the present work we synthesized: 2-imino-5-methyl 1-1, 3, 4-thiadiaze-no [5, 6-c] quinoline-4-N-oxide [IV], 4-methyl-3-hydroxy-2-phenylimidazo-lo [4, 5-c] quinoline [V] and 3-[4-dimethylaminophenyl]-10-hydroxydihy-dropyrano 4, 3-b quinoline [VI]

Synthesis of some quino line-4-spiro-2oxazole, 2-benzimidazole and 2-benzoxazel derivatives

Drugs based on 4-aminoquinoline such as chloroquine[I]and amodiaquine [II]play a key role in the treatment of malaria[1,2]. The suggestion that such drugs may be active against other diseases[3] has made it useful to synthesize new types of derivatives to look for other potential biological activities. In a previous paper [4] we have synthesized indoloquinoline [III] as large flatanalogue of I which has rapid and marked inhibition of RNA synthesis and smaller effect on protein synthesis [4]