RESUMEN
To estimate the changes in the epidimiology and histopathology of bladder cancer in rural and urban areas and their impact on the treatment prognosis. Seventy cases of bladder cancer at different stages from a rural area [El Minoufiya] were tabulated according to the age, the sex and the histopatho/ogic types. Of the.seventy pateints included 57 pateints [81.4%] were invasive [T2T3T4] and subjected to radical cystectomy at Tala Central Hospital and Shebin El Kom Teaching Hospital, group I [the rural group]. Those [57] pateints were compared with [58] pateints with invasive bladder cancer [T2, T3, T4] from a mixed area who underwent radical cystectomy in the urology department, Kasr El Ainy Hospital, group II [the mixed group]. The age of the patients included ranged between 30-83 [57.82 +/- 11.8] years and 25-82 [56.68 +/- 11.2] years in group l andll respectively with a significant increase in the age incidence than in the past. The male to female ratio was [4.6:1] in group I and [4.2:1] in group II which is higher than the known ratio of about [2.7 : 1]. The percentage of pateints according to the histopathology was as follows: Transitional Cell Carcinoma was 57.9% and 50% in group I and II, while Squamous Cell Carcinoma was 31.6% and 46.55% in group I and II respectively. The lymph node invasion was 26.3% in group I and 15.5% in group II. The bladder cancer epidemilogy and histopathology in Egypt, both in rural and urban areas has changed in the last decades not only due to decreased incidence of bilharzial infection and increased age incidence but also due to the wide exposure to different types of enviromental carcinogens