RESUMEN
The study was conducted on 40 individual: ten patients with chronic renal failure [CRF] on conservative treatment [group I], 20 patients with end stage renal disease [E.S.R.D] undergoing regular hemodialysis [group II], and 10 normal contorls. All subjects were subjected to estimation of serum creatinine, plasma fibrinogen level and assay of plasma factor XIII activity. Comparison between control group and each of group I and II have shown significant increase in plasma fibrinogen and significant decrease in plasma factor XIII activitiy in both groups of patients [I and II]. Comparison between both groups of patients [I and II] has shown that there was no significant change in all parameters studied between them. The increased plasma fibrinogen level found in our work may be due to the fact that it is an acute phase reactant protein, while the decreased factor XIII activity may be due to consumption destruction, diminished synthesis or the presence of circulating uremic inhibitor