Effects of phenobarbital and/or l-tryptophan administration on liver function, lipid and protein content in some tissues of adult male albino rats

The effects of oral administration of phenobarbital [PB] and or L- tryptophan [TR] and their withdrawal on liver function, lipid metabolism and protein content of adult male albino rats were studied. Thirty-six rats were divided into six equal groups [control, PB group, TR group, PB and TR group, PB withdrawal group and PB and TR withdrawal group]. Rats received orally 50 mg/kg body weight PB and/or TR daily for four weeks. The results suggested that PB has a drastic effect on the estimated parameters that extends after its withdrawal. TR administration may, to some extent, decline, but not abolish this effect