Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin / 한국유방암학회지

The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the efficacy of this strategy in male patients with TNBC. In this report, we describe a male patient with AR-positive TNBC who was successfully treated using an LHRH agonist after pretreatment with several lines of chemotherapy and achieved a durable response. We also review the existing evidence supporting LHRH- and AR-targeted therapy for this rare disease.

study of lymphadenopathy in children

Ninety-three lymph node biopsies were taken from 93 children with lymphadenopathy in whom surgical biopsy was indicated. Forty-eight cases were due to infective causes including tuberculosis, toxoplasmosis, dermatrophic and viral. Twenty-three cases were caused by malignant neoplasia. Eighteen cases showed reactive hyperplasia and collagen disease was detected in four cases. Biopsy taking for a final diagnosis should be done in all cases of generalized and localized lymphadenopathy, if it is not reached by conventional methods, especially when the nodes persist and have no obvious cause

Lower gastrointestinal affection in rheumatoid arthritis

The aim of this work was to study the small and large intestinal affection in rheumatoid arthritis [RA]. Twenty-five patients having rheumatoid arthritis [RA] and ten patients having osteoarthritis [OA] were compared. Duplex study of the celiac artery [CA] and superior mesenteric artery [SMA] was done. Colonoscopy and colonoscopic biopsies were taken for histopathological examination [H and E] and peroxidase staining for IgA, IgG and IgM searching for local colonic immune reaction. A statistically significant increase in peak systolic velocity [PSV], end diastolic velocity [EDV] and resistivity index [RI] of both CA and SMA was detected in the group of patients with RA compared with those with OA. Varying grades of colitis [inflammatory cell infiltration and oedema] were found in both groups, but was much pronounced in the RA group. Immunoperoxidase staining for IgA showed no significant difference between patients and controls; however a deposition of IgG and IgM immune complexes was found in the group of patients with RA not in those with OA

pathological involvement of axillary lymph nodes in cancer breast

This study has been completed on 23 patients with breast carcinoma. Their age ranged from 33 to 70 years with mean age of 48.6 years. The number of affected nodes increases in those patients with level two and three. The impact of the level of the affected nodes on their number was statistically highly significant. The impact of the stage on the number of the affected lymph nodes was statistically significant. The study showed that there was an increase in the number of the affected lymph nodes in the postmenopausal period. Modified radical mastectomy is the required treatment for breast cancer in order to provide enough specimen for the judgment of lymph node status of the patient which determines the further management whether radio or chemotherapy