two-front war: targeting synchronous metastatic pancreatic and renal cell carcinomas with the combination of gemcitabine and sunitinib

The occurrence of multiple synchronous primary tumors is extremely rare. The management plan of synchronous cancers has long been debatable and difficult mainly in tumors with different molecular characteristics. In this report, we present the second case in literature of a concomitant diagnosis of a metastatic pancreatic adenocarcinoma and a locally advanced renal cell carcinoma. We also elaborate on our management combining chemo-therapy and targeted therapy through an extensive review of literature