relation between esophageal motility disorders glycemic control in type II diabetes mellitus

Reduced values all of lower esophageal sphincter [LES] pressure, LES relaxation percentage, LES relaxation percentage, esophageal body contraction duration, velocity of waves in the esophageal body and pharyngeal pressure were noted in the diabetic patients when compared with the controls. Also, triple peaks as well as retrograde and spontaneous contractions were more frequently encountered in the diabetics. Uncontrolled diabetics showed reduced LES pressure, more prolonged esophageal contraction duration, more frequent triple peak and retrograde contraction than controlled ones. There were statistically significant negative correlations between fasting blood sugar and LES pressure and statistically significant direct correlations and retrograde contraction percentage, spontaneous contraction and pharyngeal pressure. There were statistically significant negative correlations between glycated hemoglobin and LES pressure and esophageal body contraction amplitude. It was concluded that poor glycemic control seems to adversely affect the esophageal motility parameters in patients with type II diabetes irrespective of autonomic abnormalities

Assessment of Serum Tumor Necrosis Factor-alpha and alpha-fetoprotein in HCV-related chronic liver disease patients

This study included two groups of HCV-related chronic liver disease [CLD] patients, 30 patients with compensated CLD, 30 patients with decompensated CLD in addition to 20 apparently healthy individuals who served as controls. For all the subjects, the following tests were done; complete history, clinical examination hemoglobin concentration and platelet count, liver function tests [LFTs], TNF-alpha and AFP. TNF-alpha and AFP measurement was done employing state-of-the-art solid-phase two-site chemiluminescent enzyme immunometric assay automated analyzer [immulite]. The study showed that there was significant elevation of TNF-alpha level in HCV-related CLD group in comparison to control subjects. However, no significant differences were observed between compensated and decompensate CLD groups. There was also a significant elevation of serum AFP levels in HCV-related CLD groups in comparison to control subjects. However, no significant differences were observed between compensated and decompensate CLD groups. A significant inverse correlation was found between serum albumin and serum TNF-alpha in compensated CLD group, also a significant direct correlation was found between serum ALP and serum TNF-alpha in decompensate CLD group. However, no correlation was found between serum TNF-alpha and any other assayed parameters including AFP

Regulatory Role of Interleukin Gamma on IgE in active lesions of atopic dermatitis

Thirty patients with active AD were divided into three groups, mild, moderate and sever AD, according to disease extent and severity as judged by SCORAD index. Ten apparently healthy subjects served as control were also included in this study. After detailed history taking and thorough clinical examination, serum levels of IgE, IL4 and IFN-gamma were estimated for patients and controls employing ELISA monoclonal antibody. The results were statistically analyzed for comparison and correlation. Serum IgE levels were significantly higher in all disease groups than controls. It was higher in severe AD patients than mild or moderate AD ones. Serum IL4 levels were significantly higher in all disease groups than controls. It was higher in severe AD patients than mild of moderate AD ones. Serum IFN-gamma levels were significantly lower in moderate and severe AD patients than controls. It was significantly lower in moderate and severe than mild AD patients. IL4/IFN-gamma ratio was significantly higher in all disease groups than controls. It was higher in severe than mild or moderate AD patients and in moderate than mild AD ones. Simple linear regression revealed a statistically significant direct correlation between serum IgE levels and SCORAD index only in severe AD group. Serum IL4 was significantly directly correlated to SCORAD index in moderate and severe AD patients. Serum IFN-gamma was significantly inversely correlated with SCORAD index in mid and moderate AD patients. IL4/IFN-gamma ratio was significantly directly correlated to SCORAD index in mild, moderate and severe AD patients