RESUMEN
Five compounds [1-5] were firstly reported from the genus Centaurium family Gentianaceae. They were identified as Lisianthoside 1, Secoxyloganin 2, Secologanin dimethyl acetal 3, 1, 8-Dihydroxy-3, 5, 6, 7-tetramethoxyxanthone [Demethyleustomin] 4 and 1-Hydroxy 3, 5, 6, 7, 8-pentamethoxyxanthone [Eustomin] 5. Structure elucidation was carried out with support of chemical and spectral analysis including 1D and 2D NMR experiments. All the isolated compounds showed promising antioxidant activity, liver microsomal enzymes reducing activity and CYP3A4 mRNA inhibition activity in the HepG2 cell line
RESUMEN
Fractionation and purification of the alcoholic extract of the leaves and stem -bark of Vangueria edulis cultivated in Egypt afforded thirteen compounds identified as: p-sitosterol acetate [1], stigmasterol [2], palmitic acid [3], scopoletin [4], p-coumaric acid [5], protocatechuic acid [6], esculetin [7], ethyl I-O-glucosyi-4-O-[E] caffeoyl quinate [8], kaempferol 3-O-rhamnoside, 7-O-rutinoside [9], p-sitosterol [10], ceryl alcohol [11], vanillic acid [12] and p-sitosterol-3-Q-beta-D-glucopyranoside [13]. Identification of these compounds has been established by physical, chemical and spectral data as well as comparison with authentic samples. Compounds 8 and 9 are firstly reported from a natural source while the rest of the compounds have been isolated for the first time from the genus Vangueria. The LD[50] antibacterial antifungal anti-inflammatory, antipyretic and the effect on CNS were studied