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1.
Indian J Pediatr ; 2001 Oct; 68(10): 943-4
Artículo en Inglés | IMSEAR | ID: sea-80817

RESUMEN

OBJECTIVE: The study was performed to investigate the level of serum cardiac troponin I (cTnI), a specific marker for myocardial cell damage, in the acute rheumatic carditis (RC). METHODS: Twenty seven consecutive patients with acute RC and 23 healthy children were enrolled. RESULT: cTnI level in both groups showed no statistical difference (p > 0.05). CONCLUSION: Serum cTnI level did not gain clinical use.


Asunto(s)
Biomarcadores/sangre , Niño , Preescolar , Creatina Quinasa/sangre , Humanos , Inmunoensayo/métodos , Mioglobina/análisis , Estudios Prospectivos , Cardiopatía Reumática/sangre , Troponina I/sangre
2.
Indian J Pediatr ; 2000 Mar; 67(3): 163-7
Artículo en Inglés | IMSEAR | ID: sea-81822

RESUMEN

Benzathine penicillin G (BPG) is effective for secondary prophylaxis of rheumatic fever (RF). However, interval between injections a remains a controversial matter. In a study population of 74 patients, following the initial diagnosis of RF, 3-weekly BPG (1.2 million units) regimen was started. During the first three-week period, serum penicillin concentrations were examined on the 7th, 14th and 21st days and throat culture done for group-A b hemolytic streptococcal (GABHS) infection. Ten patients (13.5%) at 21st day of injection had low serum penicillin concentration after the first BPG. GABHS was isolated in 5 patients during this period. Although two of these 5 patients had symptoms of respiratory tract infection, according to laboratory data, the other three were accepted as carriers. All 74 patients were then followed-up for rheumatic recurrence (RR) during long-term period (6 to 60 months, mean 25 +/- 5 months). There was no RR among regular (missing no more than one injection a year) group. We concluded that 3-weekly BPG regimen was satisfactory for secondary prophylaxis in RF, even though serum penicillin level was inadequate during the third week in some of the patients.


Asunto(s)
Adolescente , Niño , Esquema de Medicación , Femenino , Estudios de Seguimiento , Humanos , Masculino , Penicilina G Benzatina/administración & dosificación , Penicilinas/administración & dosificación , Recurrencia , Fiebre Reumática/prevención & control , Factores de Tiempo
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