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1.
Biol. Res ; 38(4): 329-334, 2005. ilus, tab
Artículo en Inglés | LILACS | ID: lil-425814

RESUMEN

The electrophysiological properties of nodose ganglion neurons were evaluated immediately after removing nodose ganglia from young adult rats and 3 to 10 days after nodose ganglia implantation _either alone or co-implanted with carotid bodies_ onto the chick chorioallantoic membrane. Implanted and co-implanted nodose neurons were less excitable than acutely recorded nodose neurons. Co-implanted neurons also showed reduced amplitudes for both action potentials and spike after-hyperpolarizations relative to those found in acutely recorded nodose ganglion neurons and a smaller time constant (ô) than that found in implanted neurons. In addition, no spontaneous activity was recorded from nodose ganglion neurons co-implanted with carotid bodies during 3-9 days, which suggests that functional synapses between carotid glomus cells and nodose neurons were not yet established. Results indicate the feasibility of obtaining viable nodose neurons for up to 10 days grafted onto the chick chorioallantoic membrane, where they can conserve most of their passive and active membrane properties and also are susceptible to carotid bodies trophic influences. They also suggest that nodose neurons would need more time for the development of functional synapses when grafted with carotid body glomus cells.


Asunto(s)
Animales , Recién Nacido , Adulto , Embrión de Pollo , Ratas , Cuerpo Carotídeo/anatomía & histología , Cuerpo Carotídeo/trasplante , Neuronas/trasplante , Ganglios/trasplante , Técnicas Electrofisiológicas Cardíacas
2.
Biol. Res ; 38(4): 347-352, 2005.
Artículo en Inglés | LILACS | ID: lil-425817

RESUMEN

The neuropeptide somatostatin is involved in many functions in the central nervous system as well as in the periphery. When it is centrally injected, an irreversible apnea is often developed. In the present review, we discuss the effects of somatostatin as the result of its actions at three levels of the respiratory neural network: a) by modulating the output of cranial or spinal motoneurons; b) by altering the genesis of the respiratory rhythm in the brainstem; and c) by regulating the chemosensory drive input into the respiratory pattern generator.


Asunto(s)
Humanos , Animales , Recién Nacido , Adulto , Respiración , Somatostatina/antagonistas & inhibidores , Tronco Encefálico , Tronco Encefálico/fisiología
3.
Biol. Res ; 34(2): f117, 2001. tab, graf
Artículo en Inglés | LILACS | ID: lil-303012

RESUMEN

Since its introduction two decades ago, the isolated brain stem-spinal cord preparation of neonatal rodents has been the preferred method used to reveal the mystery underlying the genesis of the respiratory rhythm. Little research using this in vitro approach has focused on the study of the central respiratory chemosensitivity. Some unexpected findings obtained with the brain stem-spinal cord preparation have added new questions that challenge our previous theoretic framework. Some of these findings are addressed here.


Asunto(s)
Animales , Tronco Encefálico , Células Quimiorreceptoras , Respiración , Médula Espinal , Acetilcolina , Tronco Encefálico , Células Quimiorreceptoras , Roedores , Médula Espinal
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