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Objectives@#This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations for the effective management of this chronic condition.The primary focus is on achieving optimal fracture prevention through a comprehensive, individualized approach. @*Methods@#A panel of experts convened to develop consensus statements by synthesizing the current literature and leveraging clinical expertise. The review encompassed long-term anti-osteoporosis medication goals, first-line treatments for individuals at very high fracture risk, and the strategic integration of anabolic and anti resorptive agents in sequential therapy approaches. @*Results@#The panelists reached a consensus on 12 statements. Key recommendations included advocating for anabolic agents as the first-line treatment for individuals at very high fracture risk and transitioning to anti resorptive agents following the completion of anabolic therapy. Anabolic therapy remains an option for in dividuals experiencing new fractures or persistent high fracture risk despite antiresorptive treatment. In cases of inadequate response, the consensus recommended considering a switch to more potent medications. The consensus also addressed the management of medication-related complications, proposing alternatives instead of discontinuation of treatment. @*Conclusions@#This consensus provides a comprehensive, cost-effective strategy for fracture prevention with an emphasis on shared decision-making and the incorporation of country-specific case management systems, such as fracture liaison services. It serves as a valuable guide for healthcare professionals in the Asia-Pacific region, contributing to the ongoing evolution of osteoporosis management.
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Objective To measure the bone mineral density on hand radiographs at the midpoint of the second metacarpal on right hand(mBMD) and metacarpal cortical index(MCI).To estimate the correlation of mBMD and MCI with bone mineral density assessed by a variety of technique at different sites.Methods We measured mBMD and MCI in 178 femeal osteoporosis patients.Results Mean mBMD and MCI were significantly lower in the patients with vertebral deformity compared to those without vertebral deformity.Both mBMD and MCI positive significantly correlated with distal forearm BMD,tibial ultrasound velocity and hip BMD and negative significantly correlated with age.Conclusion mBMD and MCI are sensitive to bone mass change in skeletal status.It can predict future fracture.