Histological changes in fetal liver after maternal treatment with panax ginseng

It is generally believed that 'natural' herbal medicines are better and safer than conventional medicines. Various in vitro studies have proved that Ginsenosides exert direct teratogenic affects on rat and mouse embryos and there is a significant variability in embryotoxic effects of different Ginsenosides. Histological examination revealed signs of hepatocyte degeneration, sinusoidal congestion and erythrocyte infiltration in the sections of liver. The changes encountered in the treated groups were dose dependant; these were marked in the high dose treated group. Ginsenosides present in the commercially available Ginseng products have teratogenic effects in vivo, although results from animal teratogenicity may not reflect the circumstances in humans. Our investigation indicates that Ginseng products have teratogenic effects in vivo and suggest that further investigations and monitoring of effects of Ginsenosides on human embryoes are warranted

Primary repair vs colostomy in colonic injuries - a two year experience at Lahore general hospital and Mayo Hospital, Lahore

The object of the study was to compare the results of primary repair in colonic injury with colostomy. 200 patients were selected, 100 being allocated to each group.All patients underwent laprotomy mostly indicated by peritoneal irritation. Most of the injuries were of the transverse colon. 22 patients underwent into exteriorization of the repaired part. Right hemicolectomy and ileocolic anastomosis was done in 30 patients. A significant morbidity occurred from wound sepsis, abdominal abscess formation and postoperative pulmonary complications. 22 patients suffered from burst abdomen and 10 developed faecal fistulas. 4 patients died. Prolonged mean hospital stay and more incidences of postoperative complications occurred in colostomy group. This shows that primary repair of colonic injuries should be done in selected cases instead of colostomy in each case

Comparative study between bupivacaine infiltration in inguinal hernia and intravenous narcotic analgesia a multicenteric study

The object of the study was to assess the pain relief after Bupivacaine infiltration in the wound in the patients following hernioraphy and to compare it with patients who received narcotic analgesia. 400 patients were selected, 200 being allocated to each group. Pain was compared according to pain scale and mobility of the patients post operatively. After the first 6 hours patients who received Bupivacaine were mobilized earlier as compared to 2nd group. This shows that long acting local anesthesia can be used in a day care surgery

Role of ileostomy in advanced cases of typhoid perforation

A study of 72 cases with typhoid perforation is presented. All the cases included in the study had more than 48hrs peritonitis with highly inflamed gut and presented late with septic shock. They were treated with exteriorization of the perforation as ileostomy. Postoperative recovery was satisfactory with minimal complications and very few mortalities. The ileostomy was closed 2 months later in all the cases