Influence of capsaicin on drug absorption and transport across biological membranes I Effect on buccal absorption of sulfathiazole

The present work aims at studying the effect of capsaicin on the buccal absorption of sulfathiazole sodium. The study was conducted on 22 volunteers by use of the Beckett-Triggs model of buccal absorption. The absorbed amount of sulfathiazole was significantly higher in eaters of capsicum in comparison with those who do not eat it. The degree of enhancement was much higher in non eaters of hot peppers